Surface coated nanodiamonds as drug delivery carriers and simultaneous imaging

表面涂层纳米金刚石作为药物输送载体和同步成像

• 批准号: DE140100318
• 负责人: Dr Pu Xiao
• 金额: $ 27.37万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100318
• 关键词: Surface; coated; nanodiamonds; drug; delivery

The design and development of next-generation nanocarriers as drug delivery platforms is an ongoing challenge in chemical and material sciences. Nanodiamonds are attractive candidates due to their biocompatibility, ease of functionalisation, and non-bleaching fluorescence. This project proposes an innovative approach to graft various polymer chains onto the surface of nanodiamonds to produce polymer-inorganic hybrid materials. This project will expand our knowledge of the influence of polymer chains on the stability of nanodiamonds and cellular uptake. The model drug gemcitabine and targeting bioactive ligands will also be conjugated onto the optimum produced hybrid materials for the drug delivery study.

设计和开发下一代纳米载体作为药物传递平台是化学和材料科学领域的一个持续挑战。纳米金刚石由于其生物相容性、易于功能化和非漂白荧光而成为有吸引力的候选材料。本项目提出了一种创新的方法，将各种聚合物链接枝到纳米金刚石表面，以生产聚合物-无机杂化材料。这个项目将扩大我们对聚合物链对纳米金刚石稳定性和细胞摄取的影响的认识。模型药物吉西他滨和靶向生物活性配体也将被偶联到最佳生产的杂化材料上，用于药物递送研究。