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MECHANISMS GOVERNING HYPERACUTE REJECTION OF THE LUNG

MECHANISMS GOVERNING HYPERACUTE REJECTION OF THE LUNG
肺部超急性排斥反应的机制
批准号:
6276824
负责人:
Richard N Pierson
金额:
$3.29万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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中文摘要
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英文摘要
An ex vivo model using human blood to perfuse pig lungs is used to study the hyperacute rejection response. Two separate components to this response have been identified, vasoconstriction and capillary leak. Using blockers of thromboxane synthesis we are able to attenuate the vasoconstriction; strategies which inhibit complement mediated injury appear to block much of the capillary leak syndrome. Transgenic strategies are being developed to address these components separately and in conjunction.
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