IMMUNE MECHANISMS OF MIDDLE EAR DISEASE

中耳疾病的免疫机制

• 批准号: 6276761
• 负责人: PHILIP FIREMAN
• 金额: $ 1.51万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276761
• 关键词: clinical research; cytokine; disease /disorder proneness /risk; eustachian tube; histamine; human subject; hypersensitivity; immunoglobulin E; immunopathology; influenzavirus A; middle ear disorder; otitis media; pathologic process; rhinitis; rhinovirus

This study explores the pathogenesis of otitis media with effusion (OME) and assesses the contribution of the various risk factors including infection, especially viral, allergy and immune competence. Experimental URI using rhinovirus (RV-39) and influenza A virus (IFA) were induced in normal susceptible human volunteers with and without a history of allergic rhinitis. Eustachian tube dysfunction was induced in 70 to 80% of infected subjects for both viruses with OME in 3% of RV-39 and 20% of IFA infected subjects. Enhanced serum IgE synthesis and WBC histamine release was documented in allergic but not in non-allergic subjects; whereas both groups had enhanced cytokines (IL-6, 8 and 10) in nasal secretions.

本研究旨在探讨渗出性中耳炎（OME）的发病机制 并评估各种风险因素的影响，包括 感染，特别是病毒，过敏和免疫能力。 实验 使用鼻病毒（RV-39）和甲型流感病毒（IFA）诱导URI， 有和没有过敏史的正常易感人类志愿者 鼻炎 在70%至80%的患者中， RV-39组和IFA组分别有3%和20%的两种病毒感染受试者发生OME 被感染的对象 增加血清IgE合成和WBC组胺释放 在过敏性受试者中有记录，但在非过敏性受试者中没有记录;而 各组鼻分泌物中的细胞因子（IL-6、8和10）增加。