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IMMUNE MECHANISMS OF MIDDLE EAR DISEASE

IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
中耳疾病的免疫机制
批准号：
6276761
负责人：
PHILIP FIREMAN
金额：
$1.51万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6276761
关键词：
clinical research cytokine disease /disorder proneness /risk eustachian tube histamine human subject hypersensitivity immunoglobulin E immunopathology influenzavirus A middle ear disorder otitis media pathologic process rhinitis rhinovirus

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中文摘要
翻译
本研究探讨渗出性中耳炎（OME）的发病机制。
英文摘要
This study explores the pathogenesis of otitis media with effusion (OME) and assesses the contribution of the various risk factors including infection, especially viral, allergy and immune competence. Experimental URI using rhinovirus (RV-39) and influenza A virus (IFA) were induced in normal susceptible human volunteers with and without a history of allergic rhinitis. Eustachian tube dysfunction was induced in 70 to 80% of infected subjects for both viruses with OME in 3% of RV-39 and 20% of IFA infected subjects. Enhanced serum IgE synthesis and WBC histamine release was documented in allergic but not in non-allergic subjects; whereas both groups had enhanced cytokines (IL-6, 8 and 10) in nasal secretions.
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IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
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