EFFECT OF HYPERINSULINEMIA ON SERUM LEPTIN LEVELS

高胰岛素血症对血清瘦素水平的影响

• 批准号: 6278206
• 负责人: Guenther Boden
• 金额: $ 1.45万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278206
• 关键词: blood chemistry; clinical research; glucose clamp technique; hormone regulation /control mechanism; human subject; hyperinsulinism; leptin; noninsulin dependent diabetes mellitus; obesity; peptide hormone

The specific aim of this study is to test the hypothesis that physiological hyperinsulinemia stimulates serum leptin release in normal human subjects. There is presently very little information relative to the mechanisms which control leptin release in humans. A rise in serum leptin could be the consquence of either hyperglycemia or hyperinsulinemia or both. In order to distinguish between these possibilities, we plan to raise insulin levels while maintaining euglycemia for 72 hr in normal and obese controls, and in obese NIDDM patients.

本研究的具体目的是检验以下假设： 生理性高胰岛素血症刺激正常人血清瘦素释放 人类实验对象目前，关于这方面的信息很少。 控制人体瘦素释放的机制。血清瘦素升高 可能是高血糖症或高胰岛素血症的结果， 两者 为了区分这些可能性，我们计划 提高胰岛素水平，同时维持正常血糖72小时， 肥胖对照组和肥胖NIDDM患者。