LIPID METABOLISM IN ABETALIPOPROTEINEMIA

这个正在进行的项目的目的是监测患者的表型 为了更好地描述营养转运（脂肪酸， 维生素E），并探讨代谢的后果和代偿性变化 这些患者缺乏含载脂蛋白B的 血浆脂蛋白 授予M01RR003340461 本方案检查了美维诺林的临床和生化疗效 （洛伐他汀）及其对胆固醇和脂蛋白代谢的影响。 一些患者将接受长期治疗， 四年以上，以确定与时间有关的影响， 治疗

The aims of this ongoing project are to monitor patients with phenotypic abetalipoprotinemia to better delineate nutrient transport (fatty acids, vitamin E) and explore the metabolic consequences and compensatory changes which occur in these patients who lack apoprotein B containing lipoproteins from plasma. GRANT M01RR003340461 This protocol examines the clinical and biochemical efficacy of mevinolin (lovastatin) and its effects upon cholesterol and lipoprotein metabolism. A number of patients will be examined on long-term therapy, for a period in excess of four years, to determine the time related effects of such treatment.