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SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER
双相情感障碍多巴胺功能的 SPECT 成像
批准号：
6277291
负责人：
Amit Anand
金额：
$2.8万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6277291
关键词：
amphetamines bipolar depression clinical research dopamine dopamine receptor human subject iodine lithium neurochemistry neurotransmitter transport radiotracer single photon emission computed tomography synapses

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英文摘要
The study of amphetamine (AMPH) induced dopamine (DA) release in bipolar disorder will explore abnormalities in presynaptic dopamine release mechanisms as well as study post-synaptic DA receptors.The general aim of this study is to evaluate potential neurochemical correlates of AMPH challenge in patients with bipolar disorder currently stable on the mood stabilizer--lithium. Patients with bipolar disorder and healthy controls matched for age, sex and ethnic origin will undergo one SPECT experiment with the D2 tracer [123I]IBZM.
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