课题基金 / 基金详情

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER
双相情感障碍多巴胺功能的 SPECT 成像
批准号：
6306196
负责人：
Amit Anand
金额：
$3.45万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6306196
关键词：
amphetamines bioimaging /biomedical imaging bipolar depression clinical research dopamine dopamine receptor human subject iodine lithium neurochemistry neurotransmitter transport radiotracer single photon emission computed tomography synapses

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相关文献

中文摘要
翻译
对双相情感障碍中安非他明（AMPH）诱导的多巴胺（DA）释放的研究，不仅可以探讨突触前多巴胺释放机制的异常，还可以研究突触后DA受体。本研究的总体目的是评估目前使用情绪稳定剂锂稳定的双相情感障碍住院患者AMPH激发的潜在神经化学相关性。双相情感障碍患者和年龄、性别和种族匹配的健康对照者将接受一项使用D2示踪剂[123I]IBZM的SPECT实验。
英文摘要
The study of amphetamne (AMPH) induced dopamine (DA) release in bipolar disorder will explore abnormalities in presynaptic dopamine release mechanisms as well as study post-synaptic DA receptors. The general aim of this study is to evaluate potential neurochemical correlates of AMPH challenge inpatients with bipolar disorder currently stable on the mood stabilizer--lithium. Patients with bipolar disorder and healthy controls matched for age, sex and ethnic origin will undergo one SPECT experiment with the D2 tracer [123I]IBZM.
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