POLYMORPHISM OF HLA DRB1 LOCUS IN COLOMBIAN, ECUADORIAN, & CHILEAN AMERINDIANS

哥伦比亚、厄瓜多尔人 HLA DRB1 基因座的多态性

• 批准号: 6277728
• 负责人: David I Watkins
• 金额: $ 5.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277728
• 关键词: Mammalia; Primates; animal tissue; genetics; human tissue; immunology; inflammation; technology /technique; transplantation

We characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. RESULTS No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA-DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported to agree with findings in other Amerind groups. The high frequencies of both DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas. OBJECTIVE: To define HLA-DRB1 alleles expressed by South American Amerindians. FUTURE DIRECTIONS This data confirms the slow rate of evolution of the DRB1 locus in South America. KEY WORDS MHC, DRB1, South America

我们在64个南方人的样本中描述了DRB 1基因型， 美洲印第安人来自智利、哥伦比亚和 厄瓜多尔. 结果17例患者中未发现新的DRB 1等位基因 不同的等位基因特征，表明快速等位基因 与HLA-B相反，在DRB 1位点不发生产生。 智利和哥伦比亚/厄瓜多尔样本的比较显示 在等位基因频率上没有大的差异。 合并 HLA-DRB 1 *0407和HLA-DRB 1 *1402等位基因出现在 频率最高（分别为38%和22%）。 遗传距离 测量显示HLA-DRB 1频率报告符合 在其他美洲人群体中的发现。 两者的高频率 DRB 1 *0407和HLA-DRB 1 *1602等位基因，以及它们的缺失 在西伯利亚的样本中，这表明除了 西伯利亚人可能参与了美洲的人口迁移。 目的：明确南美白细胞群体中HLA-DRB 1等位基因的表达， 印第安人。 未来的方向这一数据证实了 DRB 1基因在南美洲的进化 关键词MHC，DRB 1， 南美洲