IMPLANT PROSTHETIC & PERIODONTAL STUDIES IN MONKEYS

植入假肢

• 批准号: 6277479
• 负责人: MICHAEL E FRITZ
• 金额: $ 3.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277479
• 关键词: Mammalia; Primates; bioengineering /biomedical engineering; biological products; biomaterials; human tissue; model design /development; oral pharyngeal; prosthesis; surgery

We originally had thirty-six (36) animals in this project, and described two sets of experiments, one which was to place membranes in created mandibular chronic defects, keep the membranes in position for a year, regenerate bone, and place implants in regenerated bone to compare these with implants in bone which had not been regenerated. We placed the last of these implants on January 23, 1997. We allow three months for healing, and then prostheses are placed. We have all prostheses placed, which will allow exit dates during the summer of 1998, which will keep us on schedule. We are presently reducing our data. In addition, to the protocol of implant placement in regenerated bone, we have a second protocol which examines growth factors and cytokines released at various time intervals after membrane placement. We are on schedule with this, and have exited all the animals in 1997. These data are constantly being examined by Dr. Offenbacher, but we are reluctant to make any comments at this time, as the data are incomplete. We can, however, comment on the fact that using membrane technology, we are very close to our predicted value of 20% early exposure and removal. The significance of being able to regenerate bone has important scientific and clinical implications, both in the field of dentistry and in the approach to bone growth in other areas of the body. Certainly, to be able to accelerate the time that bone is grown is a very significant area of research at present, and will lead to enhancement of the dental implant field. Currently, we are also working with spinal surgeons and cranial-facial surgeons in a future protocol to regenerate spinal and cranial-facial defects. Other areas which have high clinical importance would be regeneration of mandibular bone where there are carcinomas of the mandible which require resection.

本项目最初有36只动物， 描述了两组实验，一组是将膜放置在 造成下颌骨慢性缺损，保持膜的位置， 一年，再生骨，并将植入物植入再生骨， 将其与未再生的骨中的植入物进行比较。 我们于1997年1月23日植入了最后一个植入物。 我们允许 三个月的康复期，然后再装上假肢。 我们都 假体放置，这将允许在夏季期间退出日期 1998年，这将使我们如期举行。 我们目前正在减少我们的 数据 此外，根据植入物植入方案， 再生骨，我们有第二个协议， 因子和细胞因子释放在不同的时间间隔后， 膜放置。 我们正在按计划进行，并已退出所有 1997年的动物 这些数据一直在被Dr. 奥芬巴赫，但我们不愿意在这个时候作出任何评论， 因为数据不完整。 然而，我们可以评论这样一个事实， 使用膜技术，我们非常接近我们的预测值 20%的早期暴露和移除。 能够在 再生骨具有重要的科学和临床意义， 无论是在牙科领域还是在骨生长的方法中， 身体的其他部位。 当然，为了能够加速时间 骨骼的生长是目前一个非常重要的研究领域， 并将导致牙科植入物领域的增强。 目前， 我们还与脊椎外科医生和颅面外科医生合作， 在未来的方案中再生脊柱和颅面缺损。 其他具有高度临床重要性的领域是再生 下颌骨的肿瘤， 需要切除