CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
基本信息
- 批准号:6100354
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-15 至 1999-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
CD6 is a cell surface protein expressed primarily by T-lymphocytes The
increase in CD6 expression that occurs during thymocyte maturation, and
following T-lymphocyte activation, indicates an important role for CD6 in
these processes. Exploring the function of CD6 is the focus of this
proposal.
The T cell co-stimulatory molecule CD2 is important in thymocyte
selection, and increase in CD6 are induced by stimulation of thymocyte
CD2; this raises the possibility that the CD2 induced survival-signal may
be mediated by CD6. Although CD6 has not yet been shown to be important
during thymic selection, the CD6 ligand, CD166 is expressed on thymic
epithelium, and stimulation of CD6 in chronic lymphocytic leukemia B-cells
does decrease apoptotic death. Experiments are proposed to study
developmental regulation of CD6 expression and phosphorylation by CD2, and
to determine if CD2-induced increased in CD6 expression enhance thymocyte
survival.
CD6 is also increased in activated T lymphocytes, and in autoreactive
cloned T lymphocytes. Data showing that anti-CD6 monoclonal antibody UMCD6
inhibits autoreactive responses of such clones in vitro suggests that CD6
may act as a co-stimulatory molecule in vivo during autoimmunity. Survival
of autoreactive T lymphocytes has been reported to contribute to
autoimmunity in human SLE but a role for CD6 in hum SLE, has not yet been
shown. Studies to determine if alterations in the regulation of CD6 and
CD6 phosphorylation occur in SLE T cells, and to assess the role of CD6 in
co-activation of SLE T cells are proposed in this application.
We hypothesize that the function of the T lymphocyte co-stimulatory
molecule CD6 is to enhance T-cell survival during thymocyte development,
and to transduce activating signals to mature T lymphocyte. Testing the
role of CD6 during thymic selection, and n activation in mature T
lymphocyte from SLE patients and normal controls, is expected to enhance
our understanding of the role of CD6 in human autoimmune disease.
CD6是一种主要由t淋巴细胞表达的细胞表面蛋白
项目成果
期刊论文数量(0)
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{{ truncateString('NORA SINGER', 18)}}的其他基金
CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
- 批准号:
6324599 - 财政年份:2000
- 资助金额:
-- - 项目类别:
CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
- 批准号:
6201487 - 财政年份:1999
- 资助金额:
-- - 项目类别:
EXPRESSION AND IDENTIFICATION OF CD6 LIGANDS IN PSORIASIS
银屑病中 CD6 配体的表达和鉴定
- 批准号:
6100499 - 财政年份:1998
- 资助金额:
-- - 项目类别: