CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
基本信息
- 批准号:6100354
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-15 至 1999-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
CD6 is a cell surface protein expressed primarily by T-lymphocytes The
increase in CD6 expression that occurs during thymocyte maturation, and
following T-lymphocyte activation, indicates an important role for CD6 in
these processes. Exploring the function of CD6 is the focus of this
proposal.
The T cell co-stimulatory molecule CD2 is important in thymocyte
selection, and increase in CD6 are induced by stimulation of thymocyte
CD2; this raises the possibility that the CD2 induced survival-signal may
be mediated by CD6. Although CD6 has not yet been shown to be important
during thymic selection, the CD6 ligand, CD166 is expressed on thymic
epithelium, and stimulation of CD6 in chronic lymphocytic leukemia B-cells
does decrease apoptotic death. Experiments are proposed to study
developmental regulation of CD6 expression and phosphorylation by CD2, and
to determine if CD2-induced increased in CD6 expression enhance thymocyte
survival.
CD6 is also increased in activated T lymphocytes, and in autoreactive
cloned T lymphocytes. Data showing that anti-CD6 monoclonal antibody UMCD6
inhibits autoreactive responses of such clones in vitro suggests that CD6
may act as a co-stimulatory molecule in vivo during autoimmunity. Survival
of autoreactive T lymphocytes has been reported to contribute to
autoimmunity in human SLE but a role for CD6 in hum SLE, has not yet been
shown. Studies to determine if alterations in the regulation of CD6 and
CD6 phosphorylation occur in SLE T cells, and to assess the role of CD6 in
co-activation of SLE T cells are proposed in this application.
We hypothesize that the function of the T lymphocyte co-stimulatory
molecule CD6 is to enhance T-cell survival during thymocyte development,
and to transduce activating signals to mature T lymphocyte. Testing the
role of CD6 during thymic selection, and n activation in mature T
lymphocyte from SLE patients and normal controls, is expected to enhance
our understanding of the role of CD6 in human autoimmune disease.
CD 6是主要由T淋巴细胞表达的细胞表面蛋白。
在胸腺细胞成熟期间发生的CD 6表达增加,和
T淋巴细胞活化后,表明CD 6在
这些过程。探讨CD 6的功能是本课题的重点
提议
T细胞共刺激分子CD 2在胸腺细胞中的作用
胸腺细胞的刺激诱导了CD 6的选择和增加
这就提出了一种可能性,即CD 2诱导的生存信号可能
由CD 6介导。虽然CD 6还没有被证明是重要的,
在胸腺选择过程中,CD 6配体CD 166在胸腺细胞上表达,
慢性淋巴细胞白血病B细胞中CD 6的刺激
确实减少了细胞凋亡提出实验研究
通过CD 2对CD 6表达和磷酸化的发育调节,以及
以确定CD 2诱导的CD 6表达增加是否增强胸腺细胞
生存
CD 6在活化的T淋巴细胞和自身反应性T淋巴细胞中也增加。
克隆的T淋巴细胞。数据显示抗-CD 6单克隆抗体UMCD 6
在体外抑制这些克隆的自身反应性反应表明,
可以在自身免疫过程中作为体内共刺激分子。生存
据报道,自身反应性T淋巴细胞的存在有助于
自身免疫在人类SLE中的作用,但CD 6在人类SLE中的作用,尚未被证实。
示出了研究以确定CD 6调节的改变和
CD 6磷酸化发生在SLE T细胞,为了评估CD 6在SLE T细胞中的作用,
在本申请中提出了SLE T细胞的共活化。
我们假设T淋巴细胞共刺激的功能,
分子CD 6在胸腺细胞发育期间增强T细胞存活,
并向成熟T淋巴细胞传递激活信号。测试
CD 6在胸腺选择过程中的作用,以及成熟T细胞中的n活化
来自SLE患者和正常对照的淋巴细胞,预期增强
我们对CD 6在人类自身免疫性疾病中的作用的理解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('NORA SINGER', 18)}}的其他基金
CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
- 批准号:
6324599 - 财政年份:2000
- 资助金额:
-- - 项目类别:
CD6 T LYMPHOCYTE COSTIMULATORY MOLECULE--IMMUNE DEVELOPMENT & AUTOIMMUNE DISEASE
CD6 T 淋巴细胞共刺激分子--免疫发育
- 批准号:
6201487 - 财政年份:1999
- 资助金额:
-- - 项目类别:
EXPRESSION AND IDENTIFICATION OF CD6 LIGANDS IN PSORIASIS
银屑病中 CD6 配体的表达和鉴定
- 批准号:
6100499 - 财政年份:1998
- 资助金额:
-- - 项目类别: