RESISTANCE OF NEONATAL MONKEYS TO LIVE ATTENUATED VACCINE STRAINS OF SIV

抗艾滋病是指新生儿或胎儿可能接触到 在感染的18只新生猴子中，只有2只观察到了这种疾病 与猴免疫缺陷病毒基因缺失疫苗株。 致病性仅限于未接种疫苗的母亲所生的新生儿， 也就是说，缺乏母体免疫力，而且获得了极高的 口服剂量的疫苗病毒。疫苗不会在宫内传播 在接种疫苗的母亲所生的四名新生儿中观察到了病毒 第二个三个月。我们的结果表明，活体衰减 疫苗接种方法应该仍然是预防艾滋病毒的可行选择 高危人群中的感染和疾病。

A major safety concern of using live-attenuated vaccine strategies against AIDS is the potential exposure of neonates or fetuses to vaccine virus from the mother. Here we report that high viral loads and disease were observed in only 2 of 18 neonatal monkeys infected with gene-deleted vaccine strains of simian immunodeficiency virus. Pathogenicity was restricted to neonates born to unvaccinated mothers, that is, lacking maternal immunity, and that received extremely high doses of vaccine virus orally. No in utero transmission of vaccine virus was observed in four neonates born to mothers vaccinated during the second trimester. Our results suggest that the live attenuated vaccine approach should remain a viable option for preventing HIV infection and disease in high-risk human populations.