COGNITIVE EFFECTS OF MARGINAL IRON ZINC NUTRITION IN ADOLESCENCE

意义这项研究表明，大脑功能可以 因饮食中铁和锌的边际摄入量而受损 青春期是青春期的爆发期。目标：目的 这项研究旨在剥夺恒河猴体内的铁 他们的青春期生长突飞猛进，然后决定是否提供 铁和锌作为肉类蛋白质的作用将逆转 剥夺。两项行为任务，一项注意任务和一项学习任务 任务，在整个剥夺期间和 反转，以及铁和锌缺乏的标准措施和 生长发育也进行了研究。结果血浆锌、铁含量降低 在被剥夺期间。边际缺铁缺锌 不会干扰青春期的生长，青春期也不会推迟。 所有的猴子(雌性恒河猴，30-36个月大)都经历了 血液学，其中一些被夸大了 缺铁缺锌组(8只/组)。在行为任务中 注意力表现的改善受到损害，反应迟缓 都被记录在学习任务中。肉类蛋白质补充剂出现逆转 注意力受损，但对反应速度没有影响。 未来方向我们还在研究缺铁对 使用鼠标模型的行为。一项同时使用老鼠和猴子的研究 模型和解决人类营养不良人口的关切是 正在讨论中。描述这些结果的三个摘要是 在1998年期间提交供介绍。关键词缺铁； 锌

Significance This study demonstrates that brain function can be compromised by marginal intake of iron and zinc from the diet during the period of the adolescent growth spurt. Objectives The purpose of the study was to marginally deprive rhesus monkeys of iron during their adolescent growth spurt, and then to determine whether provision of iron and zinc as meat protein would reverse the effects of the deprivation. Two behavioral tasks, an attention task and a learning tasks, were administered throughout the period of deprivation and reversal, and standard measures of iron and zinc deficiency and of growth were also studied. Results Plasma zinc and iron decreased during the deprivation period. The marginal iron and zinc deficiency did not interfere with adolescent growth and puberty was not delayed. All monkeys (female rhesus, 30-36 months old) experienced changes in hematology during the growth spurt, and some of these were exaggerated in the iron-zinc deprived group (n=8/group). In the behavioral task improvement in attention performance was impaired and slower responses were noted in the learning task. The meat protein supplement reversed the attention impairment but not the effect on speed of responding. Future Directions We are also studying iron deficiency effects on behavior using a mouse model. A study using both mouse and monkey models and addressing concerns in human malnourished populations is under discussion. Three abstracts describing these results have been submitted for presentation during 1998. KEYWORDS iron deficiency, zinc