ZINC TREATMENT TO REDUCE DURATION OF DIARRHEA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 CNPRC之前的研究有助于理解缺锌对胎儿和婴儿发育的影响。随后，在缺锌流行的人群中，补锌在国际上得到了广泛的开展。作为对这些人群中婴儿的研究的结果，补充锌与缩短腹泻持续时间和复发之间的关联被发现。在这项拟议的工作中，患有急性胃肠炎和腹泻的断奶猕猴和成年恒河猴都将接受口服锌补充剂和补水治疗，这可能会在中国大陆室内恒河猴群体中产生一种治疗腹泻的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Previous studies at the CNPRC contributed to the understanding of the impact of zinc deficiency on fetal and infant development. Subsequently, zinc supplementation has been widely undertaken internationally in human populations where zinc deficiency is edemic. As a consequence of studies of infants in these populations, an assosciation between zinc supplementation and reduced duration and recurrence of diarrhea was uncovered. In the proposed work, both weanling and adult rhesus macaques identified with acute gastroenteritis and diarrhea would receive oral zinc supplemnts and hydration therapy, which could result in a new treatment for diarrhea in the CNPRC indoor rhesus colony.