NEURONAL REPLACEMENT IN MODEL OF HUNTINGTONS DISEASE

亨廷顿病(HD)和帕金森病(PD)是 神经退行性疾病。神经病理学、神经化学和 HD的行为特征可以在非人类灵长类动物身上复制 通过立体定向损毁尾壳核的兴奋性毒性(Isacson et 艾尔)。在PD的MPTP慢性病变模型中，我们目前 联合用药治疗效果的药理学测试 通过移植胎儿神经元。房屋署的行为测试 因此，PD模型对于开发一种新的 神经退行性疾病新疗法的神经生物学基础。 HD模型决定了基底节的神经学基础 依赖性运动障碍。今年我们将继续我们的损害和 移植研究与PET和MRI研究相结合 开发一种针对HD和PD症状的治疗方法。

Huntington's disease (HD) and Parkinson's disease (PD) are neurodegenerative diseases. The neuropathological, neurochemical and behavioral hallmarks of HD can be replicated in the non-human primate by stereotaxic excitotoxic lesions of the caudate-putamen (Isacson et al. 1989). In a MPTP chronic lesion model of PD, we are currently pharmacologically testing drugs for therapeutic effects in combination with transplantation of fetal neurons. Behavioral testing of the HD and PD models is therefore of utmost importance for developing a neurobiological basis for new treatments of neurodegenerative disease. The HD model determines the neurological basis for basal ganglia dependent dyskinesia. This year we will continue our lesion and transplantations studies in combination with PET and MRI studies to develop a therapy against the symptoms seen in HD and PD.