Adminitrative Core

Isacson博士将继续担任他于2009年开始的PD IPS联盟的领导者，当时ARRA GO赠款（RC 2）资助了PD，ALS和HD联盟。他的经验和领导能力将加强PD IPS联盟的能力，以实现RFA为U24赠款设定的目标。 这个PD iPS联盟现在将被组织成三个项目核心，a）临床和遗传核心（Z。Wszoiek，核心PI），B）分化和报告基因核心（L. Studer和D. c）细胞功能和病理生理学核心（T. Dawson，核心PI）。这三个核心将由研究资源核心支持：行政（O。Isacson，核心PI）和重编程合同研究组织（CRO）（哈佛干细胞研究所和纽约干细胞基金会）（见合作函）。(For组织概况，见图1，导言）。核心包括在八个不同的机构（姆克林/哈佛、哥伦比亚、梅奥-杰克逊维尔、纪念斯隆凯夫特林、马萨诸塞州总医院/哈佛、约翰霍普金斯大学、宾夕法尼亚大学和西北大学）进行的研究。为了促进必要的协同作用和沟通渠道，以成功应对科学和技术挑战，实现联合体的目标和时间表，行政核心将提供 组织和支持U24赠款的管理。 联合会主任Ole Isacson教授负责确保协调和核心职能得到适当管理。Isacson博士在干细胞使用方面的专业知识超过十年，他卓有成效地指导了NIH资助的中心和项目，包括最近资助该项目的RC 2 GO赠款。 PD IPS Consortium。由于该联盟成员之间的互动对于实现联盟目标至关重要，Isacson博士将每2个月在所有核心PI和执行科学委员会成员之间举行一次电话会议（见图2，引言）。他将促进调查人员之间的持续合作，并将细胞送至Coriell进行存款。 在日常行政细节方面，Sandra Pohlman女士担任姆克林医院/哈佛医学院神经再生研究中心的首席管理员已有10多年。她的职责是管理资源和资金，并确保根据研究计划和研究成本类别进行适当的会计和支出。她以行政长官身份参与的有关合作协定就是例证。她以前曾为中心的大型赠款和目前的PD IPS财团开展过此类活动。 女士Pohlman担任协调员，负责研究人员就该提案、其赠款管理人员和赞助研究办公室之间的沟通，以编制和管理预算和研究报告。

Dr. Isacson will continue the role of leader of the PD IPS consortium that he began in 2009, when the ARRA GO grants (RC2s) funded the PD, ALS and HD consortia. His experience and leadership will strengthen the ability of the PD IPS consortium to achieve the goals set out in the RFA for this U24 grant. This PD iPS Consortium will now be organized into three Project Cores, a) Clinical and Genetic Core (Z. Wszoiek, core PI), b) Differentiation and Reporter Core (L. Studer and D. Krainc, core Pis), c) Cell Function and Pathophysiology Core (T. Dawson, core PI). These three cores will be supported by the research resource cores: Administration (O. Isacson, core PI) and the Reprogramming contract research organizations (CROs) (Harvard Stem Cell Institute and New York Stem Cell Foundation) (see letters of collaboration). (For overview of organization, see Fig. 1, Introduction). The cores include research studies at eight separate institutions (McLean/Harvard, Columbia, Mayo-Jacksonville, Memorial Sloan Keftering, Massachusetts General Hospital/Harvard, Johns Hopkins University, University of Pennsylvania and Northwestern University. In order to foster the synergies and lines of communication necessary for the successful achievement of the scientific and technical challenges to achieving the consortium goals and timelines, the Administrative Core will provide the organization and support for the administration of this U24 grant. The Consortium Director, Prof Ole Isacson, is responsible for ensuring that coordination and core functions are appropriately managed. Dr. Isacson's expertise in stem cell use exceeds a decade, and he has productively directed NIH-funded Centers and Programs, including the recent RC2 GO grant that currently funds this PD IPS Consortium. Because the interactions between the members of this Consortium are essential to the accomplishment of the Consortium goals, Dr. Isacson will hold a conference call every 2 months between all of the Core Pis and the members of the Executive Science Committee (see Fig. 2, Introduction). He will promote the continuous cooperation between investigators, and the sending of cells for deposit to Coriell. On the administrative day-to-day detail, Ms. Sandra Pohlman has been the chief administrator of the Center for Neuroregeneration Research at McLean Hospital/Harvard Medical School for over 10 years. Her role is to manage resources and funds, and ensure proper accounting and spending according to the research plan and research cost categories. Her involvement as an Administrator is exemplified by the cooperative agreements involved. She has carried out such activities previously for large Center grants and the current PD IPS consortium. Ms. Pohlman serves as the coordinator for communication between the investigators on this proposal, their grants administrators and sponsored research offices for preparation and administration of budgets and research reports.