DEVELOPMENT OF OCULAR REFRACTION IN MARMOSET

狨猴眼屈光的发育

• 批准号: 6277847
• 负责人: DAVID B TROILO
• 金额: $ 7.56万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277847
• 关键词: Mammalia; Primates; eye; model design /development; nervous system; psychology; surgery

The eye continues to develop from birth to maturity in such a way that as it grows in size it undergoes adjustments of its optical components and its refractive state. These adjustments are usually coordinated so that eyes grow toward emmetropia (emmetropization). Occasionally emmetropization fails and the eye becomes myopic or hyperopic. I am interested in how emmetropization works and why it occasionally goes wrong. My work to date, together with that of several others, leaves no doubt that there are both genetic and environmental contributions to the development of refractive state. The aim of my current research efforts is to study the visual mechanisms involved in the control of eye growth using the marmosets as a primate model. We study specifically (1) the nature of the visual signals that cause the eye to grow toward either myopia or hyperopia, (2) the specific structural changes in the eye as they respond to different visual conditions, (3) the mechanisms underlying these changes, and (4) the role of accommodation in the regulation of eye growth. This work has potential value for humans. Myopia is one of the 10 leading causes of blindness in the United States but its control is an old and controversial topic. My earlier work has helped to establish the importance of visual experience in the refractive development of the eye. The work in my laboratory will help provide answers to clinically relevant questions about the development of myopia in children. The work may ultimately be related to both the prediction of risk factors and the development of effective treatments for myopia in children.

以这种方式，眼睛继续从出生到成熟 随着尺寸的增长，它会经历其光学的调整 组件及其折射状态。 这些调整通常是 协调使眼睛朝着艾米特罗尼亚生长（弹药）。 偶尔弹性化失败，眼睛变成近视或 触角。 我对弹性化的工作原理以及为什么感兴趣 有时会出错。 我迄今为止的工作以及 其他几个，毫无疑问，既有遗传和 环境对折射状态发展的贡献。 我目前的研究工作的目的是研究视觉 使用Marmosets控制眼睛生长的机制 作为灵长类动物模型。 我们专门研究（1） 视觉信号会导致眼睛朝着近视或 远视，（2）眼睛的特定结构变化 响应不同的视觉条件，（3）基础机制 这些变化，以及（4）住宿在调节中的作用 眼睛生长。 这项工作对人类具有潜在的价值。 近视是一个 在美国的10个主要原因中， 控制是一个古老而有争议的话题。 我的早期工作有所帮助 确定视觉体验在折射中的重要性 眼睛的发育。 我实验室的工作将有助于提供 关于有关发展的临床相关问题的答案 儿童的近视。 这项工作最终可能与 危险因素的预测和有效治疗的发展 对于儿童的近视。