SOMATOSENSORY CORTEX & THALAMUS OF PRIMATES

为了确定高血压的解剖学基础， 水平功能，如手动灵活性和双边协调 双手 目的使用电生理记录 技术，外侧沟和后顶叶皮层的区域 将探讨，使不同领域的职能组织 可以确定。 这些地区与 丘脑，同侧皮质区，并与对侧 将通过注射少量解剖学上的 示踪剂进入电生理学定义的区域。 在追踪器之后 与注入区域相连的区域 将进行电生理学研究，以便确定 可以更好地理解地形和非地形连接。 人们会期望这些高阶场会积分 信息通过手，因此非地形连接 应该在场。 此外，我们预计密集的连接， 在对侧半球的区域，因为来自两个半球的信息 双手必须整合起来以协调整个身体的动作。 最后，与运动皮层的联系，需要帮助 感觉运动整合和直接未来运动也将是 预期 结果初步结果表明， 外侧沟与对侧沟有很强的联系 半球，特别是第二半球的手表示 躯体感觉区（SII）和顶叶腹侧区（PV）。 另一 一个重要的发现是， 在后顶叶皮层和运动皮层之间 我们终于有 发现丘脑的连接在地形学上 匹配和不匹配。 这一发现对以下方面尤为重要： 皮质可塑性的研究，其中， 大脑皮层的功能变化还有待确定。 未来 目的是将目前的结果与 人类利用功能成像技术，如fMRI和MEG 在人类和非人类灵长类动物中。 关键词第二体感 区，顶叶腹侧区，后顶叶皮质，感觉运动区 一体化

Significance To determine the anatomical substrate for higher level functions such a manual dexterity and bilateral coordination of the hands. Objectives Using electrophysiological recording techniques, areas of the lateral sulcus and posterior parietal cortex will be explored so that the functional organization of distinct areas can be ascertained. The connections of these regions with the thalamus, ipsilateral areas of the cortex, and with the contralateral hemisphere will be determined by injecting small amounts of anatomical tracers into electrophysiologically defined areas. After the tracers have transported, the regions that are connected to the area injected will be explored electrophysiologically so that the exact nature of topographic and non-topographic connections can be better understood. One would expect that these higher order fields would integrate information across the hand, and thus non-topographic connections should be present. In addition, we expect dense connections with areas in the contralateral hemisphere, since information from both hands must be integrated to coordinate movements across the body. Finally, connections with motor cortex, needed to subserve sensorimotor integration and direct future movements would also be expected. Results Preliminary results demonstrate that areas of the lateral sulcus do have strong connections with the opposite hemisphere, particularly hand representations in the second somatosensory area, SII, and parietal ventral area, PV. Another important finding is that there are relatively dense connections between posterior parietal cortex and motor cortex. Finally, we have found that connections from the thalamus are both topographically matched and mismatched. This finding is particularly important for studies of cortical plasticity, in which the anatomical substrate for functional changes in the cortex has yet to be determined. Future Directions Goals are to compare the present results with studies in humans utilizing functional imaging techniques, such as fMRI and MEG in both humans and non-human primates. KEYWORDS second somatosensory area, parietal ventral area, posterior parietal cortex, sensorimotor integration