SOMATOSENSORY SYSTEM ROLE IN MANUAL DEXTERITY & BILATERAL COORDINATION

确定体感贡献的意义 系统到复杂的灵长类行为，如手动灵巧， 手的双边协调，多式联运一体化，以及 目标导向到达所需的感应器运动集成。这个 人类这些能力的进化与 我们的感觉和运动系统的进化。因此，为了 了解这些复杂的行为是如何在人类身上产生的， 我们必须揭开我们感官组织的细节 系统，以及为复杂功能服务的神经电路。 目的研究的目的是为了揭示地形 皮层视野的组织、感受野大小、刺激 首选项和详细的田野地形连接模式 在猴子的LS和PP中，并在确定是否存在类似的视野 人类。结果近几年来，已证实功能性磁共振成像 可以有效地利用技术来确定地形 字段的组织，以及区域内的细分数量 大脑皮层。因此，在我们的电生理和 在猴子的连接研究中，我们将利用功能磁共振技术来 探索人类大脑皮层的相似区域。我们的刺激计划 选择和感兴趣的领域将以我们的结果为指导 猴子。因此，我们将从所描述的刺激开始 在上面，并将我们的努力指向侧沟和 后顶叶皮质。应用大脑皮层视野的框架 以及在我们的猴子模型中建立的与人类的联系模式， 我们可以扩大我们的刺激计划，以包括更复杂的内容 任务涉及双边操纵、目标导向达成、 和注意力。这项研究是最早的努力之一 结合人类和非人类的不同类型的技术 并承诺提供对人类更丰富的理解 躯体感觉皮层及其对更高知觉和 认知加工。应用该框架的未来发展方向 猴的大脑皮层区域和已建立的连接模式 模型到人类，我们可以扩展我们的刺激曲目，包括更多 涉及双边操纵的复杂任务，目标 定向伸展，并注意。这项研究代表了 首次尝试将人类不同类型的技术结合在一起 和非人类灵长类动物，并承诺提供更丰富的理解 人的体感皮质，及其对更高 知觉和认知加工。关键词体感区域， 新皮质，认知处理基金詹姆斯·S·麦克唐奈基金会 98-42 CNS-QUA.05

Significance To determine the contribution of the somatosensory system to complex primate behaviors such as manual dexterity, bilateral coordination of the hands, multimodal integration, and sensorimotor integration required for goal directed reaching. The evolution of these abilities in humans is firmly intertwined with the evolution of our sensory and motor systems. Thus, in order to understand how these sophisticated behaviors are generated in humans, we must uncover the details of the organization of our sensory systems, and the neural circuitry that subserves complex functions. Objectives The studies are aimed at uncovering the topographic organization of cortical fields, receptive field size, stimulus preference, and detailed topographic connection patterns of fields in LS and PP in monkeys, and at determining if similar fields exist in humans. Results Recently, it has been established that the fMRI technique can be used effectively to determine the topographic organization of fields, and the number of subdivisions within a region of cortex. Thus, in parallel with our electrophysiological and connection studies in monkeys, we will utilize fMRI techniques to explore similar regions of the neocortex in humans. Our stimulus selection and areas of interest will be guided by our results in monkeys. Thus, we will begin with stimulation like that described above, and direct our efforts to areas in the lateral sulcus and posterior parietal cortex. Applying the framework of cortical fields and patterns of connections established in our monkey model to humans, we can expand our stimulus repertoire to include more sophisticated tasks which involve bilateral manipulation, goal directed reaching, and attention. This study represents one of the first efforts to combine different types of techniques in both human and non-human prima tes, and promises to provide a richer understanding of human somatosensory cortex, and its contribution to higher perceptual and cognitive processing. Future Directions Applying the framework of cortical fields and patterns of connections established in our monkey model to humans, we can expand our stimulus repertoire to include more sophisticated tasks which involve bilateral manipulation, goal directed reaching, and attention. This study represents one of the first efforts to combine different types of techniques in both human and non-human primates, and promises to provide a richer understanding of human somatosensory cortex, and its contribution to higher perceptual and cognitive processing. KEY WORDS somatosensory area, neocortex, cognitive processing FUNDING James S. McDonnell Fdn., Grant 98-42 CNS-QUA.05