Under female control: egg defence, adaptive sex allocation, and sperm selection

女性控制下：卵子防御、适应性性别分配和精子选择

• 批准号: DE140100476
• 负责人: Dr Renee Firman
• 金额: $ 29.23万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-01-04
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100476
• 关键词: Under; female; control; egg; defence

Sexual conflict is prevalent at the gametic level, and females may respond to sperm competition via fertilisation barriers that mediate sperm entry. Surprisingly, the extent of female control over fertilisation is unknown, and the specific mechanisms that females utilise to manipulate fertilisation events are poorly understood. This project will combine innovative investigations that utilise whole organisms and in vitro fertilisation technology to study their gametes in isolation. The project offers pioneering work on gametic interactions that have not previously been characterised. It will extend knowledge on the mechanisms that underpin successful mammalian fertilisation and provide critical insight into the etiology of infertility.

性冲突在配子水平普遍存在，雌性可能通过介导精子进入的受精障碍对精子竞争做出反应。令人惊讶的是，女性控制受精的程度是未知的，女性用来操纵受精事件的具体机制知之甚少。该项目将结合联合收割机创新的调查，利用整个生物体和体外受精技术，研究他们的配子隔离。该项目提供了关于配子相互作用的开创性工作，以前没有被描述过。它将扩大知识的机制，支持成功的哺乳动物受精，并提供关键的洞察不孕症的病因。