CALIFORNIA REGIONAL PRIMATE RESEARCH CENTER

加州灵长类动物研究中心的研究计划将是 重点关注选定的与人类健康相关的领域。这项研究是 范围广泛，但强调非人类灵长类动物要解决的问题 合适的动物模型。调查在以下地点进行 行为、生理、生化和分子水平。的研究 功能正常和异常，自发性疾病如 以及实验诱导的失调进行了研究。有一个 对环境的不利影响的长期研究兴趣 各种因素。在野外和实验室条件下研究社会动力学。 条件。主要的方案单元将是行为生物学(社会 组织，物种间，差异，心理社会发展， 母婴行为和发育)；发育和生殖 生物学(配子生物学与受精、早期胚胎分化 以及植入、生殖免疫学、内分泌学和毒理学， (开发避孕药具)；呼吸系统疾病(环境氧化剂 和其他空气污染物，细胞生物学和分子生物学的 肺)；比较反转录病毒学(人类和 猿猴艾滋病)；病毒学和免疫学(猿猴艾滋病，发病机制， 免疫发病机制，慢病毒，遗传决定因素 免疫抑制疾病)和比较灵长类生物学(肝脏 生理病理学，比较遗传学，环境生理学，活体内 与定量显微镜和各种生物医学合作 研究项目)。灵长类服务(主要支助单位，由 负责高质量动物护理的专家团队和 确保人道地对待动物。该单位还进行研究 确定装卸和安置的最佳方法 研究环境中的动物)。两者之间有相当大的相互作用 研究单位，特别是比较反病毒学单位 以及病毒学和免疫学。

The research program of the California Primate Research Center will be focused in areas selected for relevance to human health. The research is broad in scope but emphasizes problems for which the nonhuman primate is the appropriate animal model. Investigations are carried out at the behavioral, physiological, biochemical and molecular levels. Studies of normal and abnormal functions are performed and spontaneous diseases as well as experimentally-induced disorders are investigated. There is a longstanding research interest in the adverse effects of environmental factors. Social dynamics are studied under field and laboratory conditions. The major program units will be Behavioral Biology (social organization, interspecies, differences, psychosocial development, maternal/infant behavior and development); Developmental and Reproductive Biology (gamete biology and fertilization, early embryonic differentiation and implantation, reproductive immunology, endocrinology and toxicology, contraceptive development); Respiratory Diseases (environmental oxidants and other air pollutants, cellular biology and molecular biology of the lung); Comparative Retrovirology (clinical and basic research in human and simian AIDS); Virology and Immunology (simian AIDS, pathogenesis, mechanisms of immunopathogenesis, lentiviruses, genetic determinants of immunosuppressive disease); and Comparative Primate Biology (hepatic physiopathology, comparative genetics, environmental physiology, intravital and quantitative microscopy and a variety of biomedical collaborative research projects). Primate Services (the major support unit, is composed of teams of specialists responsible for the high quality of animal care and ensures the humane treatment of animals. This unit also conducts studies to determine the most optimal approaches for handling and housing of animals in a research setting). There is considerable interaction between the research units, particularly the units for Comparative Retrovirology and Virology and Immunology.