UC Davis Center for Laboratory Animal Science Building J1 Renovation and Upgrade

描述(由申请者提供)：该项目的资金将用于为加州大学戴维斯分校(UC Davis)实验动物科学中心(Clas)J1大楼购买两个生物灭菌器(高压灭菌器)-一个用于动物笼子系统，另一个用于实验室产生的废物。将高压灭菌器包括在J1设施的动物隔离翼中，对于动物生物安全3级(BSL-3)传染病研究至关重要。涉及体内实验模型的研究将利用该空间进行动物感染，并用于存放受感染的鸟类、小鼠、替代动物模型(有些动物大小与家猫一样大)，以及节肢动物媒介的实验感染和传播模型(暴露在受感染动物中)。此外，由于加州大学戴维斯分校拥有太平洋西南地区卓越中心(PSWRCE)的动物核心设施，该设施将被加利福尼亚州、亚利桑那州、内华达州和夏威夷的所有参与机构使用。由于设施不足，目前通过校外赠款资助的许多工作都是在偏远地点进行的，这对研究生产率产生了不利影响。如果校园有足够的设施，加州大学戴维斯分校兽医学院和医学院以及生物科学学院和农业与环境科学学院的研究人员将从这些动物健康学科的协同中受益。该计划提供的资金将使J1设施发挥作用，用于动物BSL-3，导致传染病研究，增加人类疾病动物模型的开发，以及其他直接有利于公众健康的研究。

DESCRIPTION (provided by applicant): Funds from this program will be used to purchase two biological sterilization units (autoclaves) for the Center for Laboratory Animal Sciences (CLAS) J1 building at the University of California at Davis (UC Davis) - one for animal cage systems, the other for laboratory-generated wastes. Including the autoclaves in the animal-containment wing of the J1 facility is essential for animal biosafety level-3 (BSL-3) infectious-disease research. Studies involving in-vivo experimentation models will use the space for performing animal infections, and for holding infected avian, murine, alternative animal models (some as large as domestic felids), and experimental infection and transmission models with arthropod vectors (exposed to infected animals). Additionally, because UC Davis houses the animal core facility for the Pacific Southwestern Regional Center for Excellence (PSWRCE), the facility will be used by all of the participating institutions in California, Arizona, Nevada, and Hawaii. Due to facility deficiencies, much of the work that is currently funded through extramural grants is performed at remote sites, negatively impacting research productivity. If the campus had sufficient facilities, UC Davis investigators from the Schools of Veterinary Medicine and Medicine and the Colleges of Biological Sciences and Agriculture & Environmental Sciences would benefit from synergy of these animal health disciplines. Funds provided by this program will make the J1 facility functional for animal BSL-3 use, leading to the study of infectious disease, increased development of animal models of human disease, and other research of direct benefit to public health.