UC Davis Center for Laboratory Animal Science Building J1 Renovation and Upgrade

描述（由申请人提供）：本项目的资金将用于为加州大学戴维斯分校（UC Davis）的实验动物科学中心（CLAS）J1楼购买两台生物灭菌装置（高压灭菌器）-一台用于动物笼系统，另一台用于实验室产生的废物。在J1设施的动物收容翼中包括高压灭菌器对于动物生物安全3级（BSL-3）传染病研究至关重要。涉及体内实验模型的研究将使用空间进行动物感染，并用于保存受感染的禽类、鼠类、替代动物模型（有些与家养猫科动物一样大），以及节肢动物媒介的实验感染和传播模型（暴露于受感染的动物）。此外，由于加州大学戴维斯分校为太平洋西南地区卓越中心（PSWRCE）提供动物核心设施，该设施将被加州、亚利桑那州、内华达州和夏威夷的所有参与机构使用。由于设施不足，目前通过校外赠款资助的大部分工作都是在偏远地区进行的，对研究生产力产生了负面影响。如果校园有足够的设施，来自兽医学院和医学院以及生物科学学院和农业与环境科学学院的加州大学戴维斯分校研究人员将从这些动物健康学科的协同作用中受益。该计划提供的资金将使J1设施能够用于动物BSL-3，从而研究传染病，增加人类疾病动物模型的开发，以及其他直接有益于公共卫生的研究。

DESCRIPTION (provided by applicant): Funds from this program will be used to purchase two biological sterilization units (autoclaves) for the Center for Laboratory Animal Sciences (CLAS) J1 building at the University of California at Davis (UC Davis) - one for animal cage systems, the other for laboratory-generated wastes. Including the autoclaves in the animal-containment wing of the J1 facility is essential for animal biosafety level-3 (BSL-3) infectious-disease research. Studies involving in-vivo experimentation models will use the space for performing animal infections, and for holding infected avian, murine, alternative animal models (some as large as domestic felids), and experimental infection and transmission models with arthropod vectors (exposed to infected animals). Additionally, because UC Davis houses the animal core facility for the Pacific Southwestern Regional Center for Excellence (PSWRCE), the facility will be used by all of the participating institutions in California, Arizona, Nevada, and Hawaii. Due to facility deficiencies, much of the work that is currently funded through extramural grants is performed at remote sites, negatively impacting research productivity. If the campus had sufficient facilities, UC Davis investigators from the Schools of Veterinary Medicine and Medicine and the Colleges of Biological Sciences and Agriculture & Environmental Sciences would benefit from synergy of these animal health disciplines. Funds provided by this program will make the J1 facility functional for animal BSL-3 use, leading to the study of infectious disease, increased development of animal models of human disease, and other research of direct benefit to public health.