SEARCH FOR IMPAIRMENT IN PTH-MEDIATED RENAL CALCIUM TRANSPORT

寻找 PTH 介导的肾钙转运受损

• 批准号: 6278548
• 负责人: B L RIGGS
• 金额: $ 2.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278548
• 关键词: aging; calcium; clinical research; hormone regulation /control mechanism; human subject; osteopenia; osteoporosis; parathyroid hormones; pathologic bone resorption; renal tubular transport

The overall objective of this study is to develop a more coherent understanding of the etiology and pathophysiology of the age-related bone loss that leads to osteoporosis. We initially reported in an abstract that compared to normal postmenopausal women, women with postmenopausal osteoporosis have decreased tubular reabsorption of calcium and sustained renal calcium wasting. It was independent of PTH action and concluded that a primary defect in renal calcium conservation may be a major cause of the negative calcium balance in postmenopausal osteoporosis. We have since expanded this project to include normal and osteoporotic postmenopausal women on estrogen to test if estrogen corrects the defect in renal calcium conservation in women with osteoporosis. We are in the process of analyzing those samples. A further extension of this study is explored in our protocol, 802-95.

本研究的总体目标是制定一个更加连贯的 了解与年龄相关的 导致骨质疏松症的骨质流失。 我们最初在一份摘要中报告说，与正常人相比， 绝经后妇女，患有绝经后骨质疏松症的妇女， 肾小管钙重吸收减少和持续肾钙 浪费 这是独立的PTH行动，并得出结论，主要是 肾钙保存缺陷可能是导致肾功能衰竭的主要原因。 绝经后骨质疏松症的负钙平衡 我们已经 将该项目扩展到包括正常和绝经后妇女 服用雌激素的妇女，以测试雌激素是否能纠正肾功能缺陷。 骨质疏松症妇女的钙保存。 我们正在 分析这些样本 本研究的进一步扩展是 在我们的方案802-95中进行了探索。