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GENETIC FACTORS IN OVARIAN CANCER AMOUNG ASHKENAZI JEWISH WOMEN

GENETIC FACTORS IN OVARIAN CANCER AMOUNG ASHKENAZI JEWISH WOMEN
德系犹太妇女卵巢癌的遗传因素
批准号：
6278351
负责人：
BETH Y. KARLAN
金额：
$3.92万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6278351
关键词：
Jewish brca gene clinical research family genetics female gene frequency gene mutation genetic counseling human subject neoplasm /cancer genetics oncogenes ovary neoplasms women's health

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中文摘要
翻译
BRCA1基因的突变已经被确定为一些原因， 乳腺癌和卵巢癌的遗传形式。 在 德系犹太人群体，特定的突变似乎发生与 流行率上升。 这项研究是为了确定 德系犹太人中两种最常见的BRCA1突变的频率 患卵巢癌的女性
英文摘要
Mutations in the BRCA1 gene have been identified to account for some of the inherited forms of breast cancer and ovarian cancer. In the Ashkenazi Jewish population, specific mutations appear to occur with increased prevalence. This study was undertaken to determine the frequency of the two most common BRCA1 mutations in Ashkenazi Jewish women with ovarian cancer.
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