GENETIC DEFINITION AND PHENOTYPE DETERMINANTS OF HUMAN OVARIAN CARCINOMA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1) establishing a human ovarian tissue and clinical data base core facilitly to support the proposed projects and future investigations, 2) identifying genes which are differentially expressed in ovarian cancers and thereby discovering biomarkers for early detection, 3) studying ovarian tumorigenesis in ovarian tissues obtained from germline BRCA1 mututaion carrier to better understand the interaction between mutational inactivation of BRCA1, the cellular caretaker gene and p53, the cellular gatekeeper gene, and 4) developing a genetically defined mouse model of epithelial ovarian cancer.