Does caffeine affect the development of the very immature brain: dose response relationship?

咖啡因是否会影响非常不成熟的大脑的发育：剂量反应关系？

• 批准号: nhmrc : 628312
• 负责人: A/Pr Jeanie Cheong
• 金额: $ 44.57万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-caffeine-affect-response-relationship/80875
• 关键词: Does; caffeine; affect; development; very

Premature birth is a major health problem worldwide. Preterm babies often develop apnoea of prematurity (AOP), which is commonly treated with caffeine. Trials indicate that preterm babies treated with low dose caffeine have less neurodevelopmental disabilities at 18 months. Higher doses of caffeine are often needed to reduce AOP but the risk of this is unknown. We will study the short and long-term effects of increasing doses of caffeine on the developing brain in a long-gestation species.

早产是世界范围内的一个主要健康问题。早产儿通常会出现早产儿呼吸暂停（AOP），通常用咖啡因治疗。试验表明，接受低剂量咖啡因治疗的早产儿在18个月时的神经发育障碍较少。通常需要更高剂量的咖啡因来降低AOP，但其风险尚不清楚。我们将研究增加剂量的咖啡因对长期妊娠物种大脑发育的短期和长期影响。