PK OF LIQUID IBUPROFEN IN INFANTS, TODDLERS AND PRESCHOOLERS W/ CYSTIC FIBROSIS

口服利多卡因可减轻囊性纤维化气道炎症损伤 布洛芬治疗提供的气道损伤处于其早期阶段。最 因此，提供这种治疗的重要时间是在 婴幼儿CF气道炎症和损伤的早期阶段 不能服用布洛芬片剂的患者;需要液体制剂， 对待他们。 液体布洛芬的药代动力学尚不清楚， CF<6岁的儿童，在婴儿、幼儿、 和学龄前儿童从年龄较大的儿童和成人CF。的 液体布洛芬的吸收也可能不同于片剂 布洛芬 本研究将描述液体的药代动力学 布洛芬用于婴儿、幼儿和学龄前儿童。预计 液体布洛芬吸收更快，更均匀， 完全比片剂配方。因此，血浆浓度 会上升得更快，更快达到峰值，然后以更可预测的方式衰减。 时尚.

The inflammatory airway injury in Cystic Fibrosis can be lessened by oral ibuprofen therapy provided airway injury is in its early stages. The most important time to offer this therapy is, therefore, before or during the early phases of airway inflammation and injury in young children with CF who cannot take tablets of ibuprofen; liquid formulations are needed to treat them. The pharmacokinetics of liquid ibuprofen is not known in children with CF<6 years of age, and it may differ in infants, toddlers and preschool children from older children and adults with CF. The absorption of liquid ibuprofen may also differ from tablet formulations of ibuprofen. This study will describe the pharmacokinetics of liquid ibuprofen in infants, toddlers and preschool children. It is anticipated that liquid ibuprofen is absorbed faster, more uniformly and more completely than tablet formulation. As a result, plasma concentrations will rise faster, reach a peak sooner and then decay in a more predictable fashion.