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COMPARISON OF SINGLE DOSE AMINOGLYCOSIDE VERSUS CONVENTIONAL THERAPY

COMPARISON OF SINGLE DOSE AMINOGLYCOSIDE VERSUS CONVENTIONAL THERAPY
单剂量氨基糖苷与传统疗法的比较
批准号：
6280874
负责人：
JAY H TUREEN
金额：
$2.39万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6280874
关键词：
adolescence (12-20) aminoglycoside antibiotics beta lactam antibiotic child (0-11) clinical research clinical trials cystic fibrosis health care cost /financing human subject human therapy evaluation metabolism disorder chemotherapy respiratory infections respiratory pharmacology

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中文摘要
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英文摘要
This is a randomized controlled investigator blinded study comparing single daily dosing of aminoglycoside vs divided dosing combined with beta-lactam antibiotic in children aged 6 to 18 with cystic fibrosis and acute pulmonary exacerbation. Clinical efficacy will be measured using sequential sputum bacterial titers, and pulmonary function tests. Toxicity will be evaluated using audiograms and serum creatinine. Potential cost savings will be based on length of therapy and time to subsequent hospitalization.
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Cystic fibrosis once daily aminoglycoside collaborative trial
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