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PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA

PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA
高剂量他莫昔芬治疗转移性黑色素瘤的 III 期研究
批准号：
6280078
负责人：
EDWARD F MCCLAY
金额：
$2.73万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6280078
关键词：
cis platinum compound clinical research combination cancer therapy dosage drug interactions drug screening /evaluation human subject human therapy evaluation melanoma metastasis neoplasm /cancer chemotherapy neoplastic cell tamoxifen

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英文摘要
The purpose of this grant is to explore the possible mechanisms of interaction between tamoxifen and cisplatin in human malignant melanoma cells. This grant involves the conduct of a phase I and phase II clinical trial in patients with metastatic melanoma to investigate the clinical importance of synergy between tamoxifen and cisplatin. Correlative studies are planned to determine in vivo predicators of clinicalresponse. Additionally, in vivo studies are planned to determine the underlying mechanism of synergy between tamoxifen and cisplatin.
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PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA
PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA
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