PHASE III STUDY OF HIGH DOSE TAMOXIFEN IN METASTATIC MELANOMA

这笔赠款的目的是探索可能的机制， 他莫昔芬与顺铂在人恶性黑色素瘤中的相互作用 细胞。这笔赠款涉及进行一期和二期临床试验。 试验在转移性黑色素瘤患者中的临床研究 他莫昔芬与顺铂协同作用的重要性。相关 计划进行研究以确定临床反应的活体预测因子。 此外，计划进行体内研究，以确定潜在的 他莫昔芬与顺铂的协同作用机制。

The purpose of this grant is to explore the possible mechanisms of interaction between tamoxifen and cisplatin in human malignant melanoma cells. This grant involves the conduct of a phase I and phase II clinical trial in patients with metastatic melanoma to investigate the clinical importance of synergy between tamoxifen and cisplatin. Correlative studies are planned to determine in vivo predicators of clinicalresponse. Additionally, in vivo studies are planned to determine the underlying mechanism of synergy between tamoxifen and cisplatin.