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FULLERENE BASED INHIBITORS OF HIV 1 PROTEASE

FULLERENE BASED INHIBITORS OF HIV 1 PROTEASE
基于富勒烯的 HIV 1 蛋白酶抑制剂
批准号：
6280179
负责人：
SIMON H FRIEDMAN
金额：
$0.02万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-07-01 至 1999-06-30
来源：
https://reporter.nih.gov/project-details/6280179
关键词：
AIDS biological products biomaterials biomedical resource immunology infection inflammation lymphatic system virus

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英文摘要
We have recently refined our fullerene based inhibitors of the HIV protease. The facilities of the Computer Graphics Laboratory were for both the original investigations as well as the preparation of figures for a submitted paper. The specific facilities utilized were the graphical workstations and the MidasPlus and DMS software. These were used to examine and analyze model complexes generated by the program DOCK of various fullerene inhibitors and the active site of the HIV protease. This process was used to determine which of a variety of molecules would be most advantageous to synthesizeand test.
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