Investigating Sex Differences In Beta Cell Calcium Handling

研究 β 细胞钙处理的性别差异

• 批准号: NE/X006662/1
• 负责人: Aileen King
• 金额: $ 1.44万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FX006662%2F1
• 关键词: Investigating; Sex; Differences; Beta; Cell

MRC : Lydia Daniels Gatward : MR/N013700/1Diabetes is a disease affecting around 10% of the population which is caused by an inability to regulate blood glucose levels. Sex differences exist in diabetes; men have increased incidence of type 2 diabetes compared to women, an effect which is lost after the menopause. Blood glucose levels are normally tightly controlled by insulin release from beta cells in the pancreas, a process which involves calcium signalling. Dysregulated calcium signalling in these cells disrupts insulin release and has been associated with the development of diabetes. Considering the sex differences in diabetes and findings that other tissues show sex differences in calcium handling, we want to investigate whether sex differences exist in calcium handling in beta cells. To do this, we plan to use state-of-the-art imaging technology to study calcium signalling in two of the main calcium storage compartments in beta cells isolated from non-diabetic and diabetic male and female mice. Understanding these pathways in more detail could help determine whether the sex of the patient should be more carefully considered when choosing treatments for diabetes.

MRC：Lydia Daniels Gatward：MR/N013700/1糖尿病是一种影响约 10% 人口的疾病，其原因是无法调节血糖水平。糖尿病存在性别差异；与女性相比，男性 2 型糖尿病的发病率更高，但这种影响在绝经后消失。血糖水平通常受到胰腺β细胞释放胰岛素的严格控制，这一过程涉及钙信号传导。这些细胞中钙信号传导失调会破坏胰岛素释放，并与糖尿病的发生有关。考虑到糖尿病中的性别差异以及其他组织在钙处理方面表现出性别差异的发现，我们想要研究β细胞中钙处理方面是否存在性别差异。为此，我们计划使用最先进的成像技术来研究从非糖尿病和糖尿病雄性和雌性小鼠中分离出的β细胞中两个主要钙存储室中的钙信号传导。更详细地了解这些途径可以帮助确定在选择糖尿病治疗方法时是否应该更仔细地考虑患者的性别。