COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER

描述（申请人的描述）：用于以下疾病的遗传筛选方法 遗传性非息肉病性结直肠癌（HNPCC）发展迅速， 可能很快就会从实验室和遗传学专业中心转移到 全科医生办公室和其他门诊站点。 现在有一个 需要更好地了解遗传筛查对HNPCC的影响， 经济和以患者为中心的生活质量观点。 响应于 NCI的职业发展奖（霍华德特明奖），候选人 建议：（1）建立灵活的数学仿真模型， 估计替代基因筛查的成本效益， HNPCC易感性的筛查后监测策略;（2）估计 HNPCC基因筛查对健康相关生活质量的影响 那些接受测试的人。 该研究项目预计， 为响应国家癌症研究所的要求， RFA CA-96-011研究所，“流行病学合作家庭登记处” 结肠癌的研究。“本登记研究的患者将被招募， 参与健康相关生活质量调查。 的一部分 职业发展计划，候选人将参加遗传学课程， 公共卫生和社区医学学院的遗传流行病学 在华盛顿大学。 这位名人的导师妮可·厄本 科学博士，具有丰富的数学建模和指挥经验 卵巢癌和乳腺癌的成本效益分析。 候选人的 长期目标是（1）制定适用于 对常见获得性肺炎基因筛查的成本效益分析 恶性肿瘤;（2）利用成本效益分析的结果， 遗传筛查测试作为临床实践发展的一部分 针对初级保健的遗传筛查指南 医生

DESCRIPTION (Applicant's Description): Methods of genetic screening for hereditary nonpolyposis colorectal cancer (HNPCC) are rapidly developing, and may soon move from the laboratory and genetics specialty centers to generalist physicians' offices and other outpatient sites. There is now a need to better understand the impact of genetic screening for HNPCC from an economic and patient-centered quality-of-life perspective. In response to the NCI's Career Development Award (Howard Temin Award), the candidate proposes to: (1) develop a flexible mathematical simulation model to estimate the cost-effectiveness of alternative genetic screening and postscreening surveillance strategies for HNPCC susceptibility; (2) estimate the impact of genetic screening for HNPCC on health-related quality of life of those who undergo testing. The research project anticipates the development of a colorectal cancer registry in response to National Cancer Institute RFA CA-96-011, "Cooperative Family Registry for Epidemiologic Studies of Colon Cancer." Patients from this registry will be recruited to participate in the health-related quality-of-life survey. As part of the career development plan, the candidate will take course work in genetics and genetic epidemiology from The School of Public Health and Community Medicine at the University of Washington. The c a ndidate's mentor, Nicole Urban, Sc.D., has extensive experience in mathematical modeling and conducting cost-effectiveness analysis of ovarian and breast cancer. The candidate's long-term goals are to (1) develop general research guidelines for applying cost-effectiveness analysis to genetic screening for commonly acquired malignancies; (2) utilize the results from cost-effectiveness analyses of genetic screening tests as part of the development of clinical practice guidelines for genetic screening that are directed at primary care physicians.