CYTOKINES--THEIR ROLE IN COXSACKIE VIRUS B3 MYOCARDITIS

在这项拨款提案中讨论的研究解决了 细胞因子在病毒性心肌炎急性期及晚期发展中的作用 CB3感染易感A/J小鼠的相性自身免疫性心肌炎 人柯萨奇病毒性心肌炎模型的建立。实验将检查当地 心脏中细胞因子的产生对CB3感染或 肌球蛋白免疫。细胞因子对炎性细胞的影响 种群及其活性以及细胞因子对心脏功能的影响 将检查心肌细胞的收缩能力和生理学。的影响 抗细胞因子治疗对心肌炎的发展也会有影响 检查过了。 所有研究都将在约翰霍普金斯大学卫生学院进行， 公共卫生。实验室设备齐全，容纳了所有 完成所述实验所需的设备。

The research discussed in this grant proposal addresses the role of cytokines in the development of acute phase viral myocarditis and late phase autoimmune myocarditis in CB3- infected susceptible A/J mice, a model of human coxsackievirus myocarditis. Experiments will examine local production of cytokines in the heart in response to CB3 infection or myosin immunization. The effects of cytokines on inflammatory cell populations and their activity, and the effects of cytokines on cardiac myocyte contractility and physiology will be examined. The effect of anticytokine therapy on the development of myocarditis will also be examined. All research will be conducted in the Johns Hopkins School of Hygiene and Public Health. The laboratories are well equipped, and contain all equipment necessary to complete the described experiments.