CYTOKINES--THEIR ROLE IN COXSACKIE VIRUS B3 MYOCARDITIS

细胞因子——它们在柯萨奇病毒 B3 心肌炎中的作用

• 批准号: 2751011
• 负责人: SUSAN L HILL
• 金额: $ 9.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2751011
• 关键词: Coxsackievirus; autoimmune disorder; cytokine; disease /disorder model; enzyme linked immunosorbent assay; heart contraction; immunization; immunocytochemistry; immunotherapy; in situ hybridization; inflammation; interferon gamma; interleukin 1; interleukin 6; laboratory mouse; myocarditis; myosins; nonhuman therapy evaluation; polymerase chain reaction; transforming growth factors; tumor necrosis factor alpha

The research discussed in this grant proposal addresses the role of cytokines in the development of acute phase viral myocarditis and late phase autoimmune myocarditis in CB3- infected susceptible A/J mice, a model of human coxsackievirus myocarditis. Experiments will examine local production of cytokines in the heart in response to CB3 infection or myosin immunization. The effects of cytokines on inflammatory cell populations and their activity, and the effects of cytokines on cardiac myocyte contractility and physiology will be examined. The effect of anticytokine therapy on the development of myocarditis will also be examined. All research will be conducted in the Johns Hopkins School of Hygiene and Public Health. The laboratories are well equipped, and contain all equipment necessary to complete the described experiments.

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