MARTRLLC 金属蛋白酶在糖尿病肾病发展中的作用-猫眼课题宝

MARTRLLC 金属蛋白酶在糖尿病肾病发展中的作用

批准号：

6283018

负责人：

LEONARD ARBEIT

金额：

$2.44万

依托单位：

STATE UNIVERSITY NEW YORK STONY BROOK

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-06-04 至 1998-11-30

来源：

https://reporter.nih.gov/project-details/6283018

关键词：

albuminuria basement membrane clinical research collagenase diabetes mellitus therapy diabetic nephropathy disease /disorder etiology glomerulosclerosis human subject human therapy evaluation insulin dependent diabetes mellitus kidney disorder chemotherapy pathologic process periodontium disorder proteinuria renal glomerulus tissue inhibitor of metalloproteinases

项目摘要

项目成果

LEONARD ARBEIT的其他基金

相似基金

相关文献

中文摘要

翻译

假设：人类糖尿病肾病是由一个过度

英文摘要

HYPOTHESIS: That human diabetic nephropathy is caused by an over- production of gelatinases resulting in damage to the glomerular basement membrane followed by glomerulosclerosis caused by the abnormal wound healing. SPECIFIC AIMS: 1. Are renal gelatinases increased in human Type I diabetes mellitus? 2. Is there a correlation with increase in renal gelatinases and the development of microalbuminuria? 3. Does inhibition of gelatinases in patients with microalbuminuria result in decreased albumin leak? 4. Does inhibition of gelatinases in patients with overt Diabetic nephropathy result in decreased proteinuria? 5. Does inhibition of gelatinases in Type I DM result in a decrease in the rate of progression of diabetic nephropathy? 6. Does anti-gelatinase therapy also reduce the severity of periodontal disease in these diabetic patients?

期刊论文(0)

专著(0)

科研奖励(0)

会议论文

ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY

批准号：

6123136
项目类别：
资助金额：

$5.08万
财政年份：

--
负责人：

LEONARD ARBEIT
依托单位：

STATE UNIVERSITY NEW YORK STONY BROOK

海外基金