ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY

MARTRLLC 金属蛋白酶在糖尿病肾病发展中的作用

• 批准号: 6123136
• 负责人: LEONARD ARBEIT
• 金额: $ 5.08万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6123136
• 关键词: albuminuria; basement membrane; clinical research; collagenase; diabetes mellitus therapy; diabetic nephropathy; disease /disorder etiology; glomerulosclerosis; human subject; human therapy evaluation; insulin dependent diabetes mellitus; kidney disorder chemotherapy; pathologic process; periodontium disorder; proteinuria; renal glomerulus; tissue inhibitor of metalloproteinases

HYPOTHESIS: That human diabetic nephropathy is caused by an over- production of gelatinases resulting in damage to the glomerular basement membrane followed by glomerulosclerosis caused by the abnormal wound healing. SPECIFIC AIMS: 1. Are renal gelatinases increased in human Type I diabetes mellitus? 2. Is there a correlation with increase in renal gelatinases and the development of microalbuminuria? 3. Does inhibition of gelatinases in patients with microalbuminuria result in decreased albumin leak? 4. Does inhibition of gelatinases in patients with overt Diabetic nephropathy result in decreased proteinuria? 5. Does inhibition of gelatinases in Type I DM result in a decrease in the rate of progression of diabetic nephropathy? 6. Does anti-gelatinase therapy also reduce the severity of periodontal disease in these diabetic patients?

假设：人类糖尿病肾病是由过度饮食引起的 明胶酶的产生导致肾小球基底损伤 异常伤口引起的膜继发肾小球硬化 康复。 具体目标： 1. 人类 I 型糖尿病患者肾明胶酶是否升高？ 2. 肾明胶酶升高与肾病有相关性吗？ 微量白蛋白尿的发展？ 3. 明胶酶抑制对微量白蛋白尿患者有效果吗 白蛋白泄漏减少？ 4. 抑制明胶酶对明显糖尿病患者有效吗 肾病会导致蛋白尿减少吗 5. 抑制 I 型 DM 中的明胶酶是否会导致 糖尿病肾病的进展速度？ 6. 抗明胶酶治疗也能减轻牙周病的严重程度吗？ 这些糖尿病患者得了什么病？