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ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY

ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY
MARTRLLC 金属蛋白酶在糖尿病肾病发展中的作用
批准号：
6123136
负责人：
LEONARD ARBEIT
金额：
$5.08万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6123136
关键词：
albuminuria basement membrane clinical research collagenase diabetes mellitus therapy diabetic nephropathy disease /disorder etiology glomerulosclerosis human subject human therapy evaluation insulin dependent diabetes mellitus kidney disorder chemotherapy pathologic process periodontium disorder proteinuria renal glomerulus tissue inhibitor of metalloproteinases

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中文摘要
翻译
假设：人类糖尿病肾病是由过量的 明胶酶的产生导致肾小球基底膜的损伤 膜继发肾小球硬化由异常创面引起 治愈。 具体目标： 1.肾脏明胶酶在人类I型糖尿病中是否升高？ 2.肾组织明胶酶升高与肾功能损害是否存在相关性 微量白蛋白尿的进展？ 3.抑制微量白蛋白尿患者的明胶酶是否有结果 在减少白蛋白泄漏方面？ 4.对显性糖尿病患者明胶酶的抑制作用 肾病导致蛋白尿减少？ 5.抑制I型糖尿病患者的明胶酶是否会导致 糖尿病肾病的进展速度？ 6.抗明胶酶疗法是否也能降低牙周病变的严重程度 这些糖尿病患者中的疾病吗？
英文摘要
HYPOTHESIS: That human diabetic nephropathy is caused by an over- production of gelatinases resulting in damage to the glomerular basement membrane followed by glomerulosclerosis caused by the abnormal wound healing. SPECIFIC AIMS: 1. Are renal gelatinases increased in human Type I diabetes mellitus? 2. Is there a correlation with increase in renal gelatinases and the development of microalbuminuria? 3. Does inhibition of gelatinases in patients with microalbuminuria result in decreased albumin leak? 4. Does inhibition of gelatinases in patients with overt Diabetic nephropathy result in decreased proteinuria? 5. Does inhibition of gelatinases in Type I DM result in a decrease in the rate of progression of diabetic nephropathy? 6. Does anti-gelatinase therapy also reduce the severity of periodontal disease in these diabetic patients?
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ROLE OF MARTRLLC METALLOPROTEINASES IN DEVELOPMENT OF DIABETIC NEPHROPATHY
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