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ACTG 273--PHASE I/II STUDY OF HIVIG IN SLOWING PROGRESSION OF DISEASE

ACTG 273--PHASE I/II STUDY OF HIVIG IN SLOWING PROGRESSION OF DISEASE
ACTG 273--HIVIG 减缓疾病进展的 I/II 期研究
批准号：
6282691
负责人：
Peter James Krause
金额：
$1.85万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6282691
关键词：
AIDS therapy antiviral antibody child (0-11) clinical research clinical trial phase I human immunodeficiency virus human subject human therapy evaluation immunoglobulin G pathologic process pediatric AIDS

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中文摘要
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英文摘要
This is a Phase I study of HIV-infected subjects age 2-12 years, who have been maintained on antiretroviral therapy for > 6 months, whose CD4 count is > 200 were given HIVIG, randomized to 1 of 3 doses. Six monthly infusions were given, then a 3 month, and monthly follow-up visits. The objectives of this study are to evaluate the safety and tolerance; evaluate dosage by serial measurements of IgG, P-24 antigen and rubella antibody titers; and to evaluate antiviral activity of HIVIG by assays of viral burden. The study has been closed.
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