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SINGLE DOSE RESPONSE FOR CRH IN NORMAL AND SLEEP DISORDER PATIENTS

SINGLE DOSE RESPONSE FOR CRH IN NORMAL AND SLEEP DISORDER PATIENTS
正常和睡眠障碍患者的 CRH 单剂量反应
批准号：
6283106
负责人：
ALEXANDROS N VGONTZAS
金额：
$2.16万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6283106
关键词：
catecholamines clinical research corticotropin releasing factor cortisol dosage hormone regulation /control mechanism hormone therapy human subject human therapy evaluation hypothalamic pituitary adrenal axis sleep apnea sleep disorders urinalysis

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中文摘要
翻译
本研究的总体目标是评估患者的下丘脑轴
英文摘要
The overall goal of this study is to assess the HPA axis in patients with sleep disorders and normal controls. The specific objectives of this study are : 1) to assess the catecholamines and their metabolites and free cortisol in twenty four hour urine collections on subjects with sleep disorders and age, sex and weight matched controls; and 2) to asses the pituitary adrenal response to CRH test in the same subjects. We hypothesize that patients with sleep disorders associated with hyperarousal e.g. insomnia or significant sleep disruption e.g.apnea will be associated with an activation of the HPA axis while patients with disorders associated with hypoarousal i.e.idiopathic hypersomnia will be associated with hypofunctioning of the axis.
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