SINGLE DOSE RESPONSE FOR CRH IN NORMAL AND SLEEP DISORDER PATIENTS

这项研究的总体目标是评估患者的HPA轴。 有睡眠障碍和正常对照组。的具体目标 本研究的主要目的是：1)对儿茶酚胺及其代谢产物进行评价 和24小时尿液收集中的游离皮质醇 睡眠障碍和年龄、性别和体重匹配的对照组；以及2)到 评估相同受试者的垂体-肾上腺对CRH试验的反应。 我们假设睡眠障碍患者与 高度觉醒，如失眠或严重睡眠障碍，如呼吸暂停 会与HPA轴的激活有关，而患者 患有与低觉醒相关的障碍，即特发性睡眠过多 会与脑轴功能减退有关。

The overall goal of this study is to assess the HPA axis in patients with sleep disorders and normal controls. The specific objectives of this study are : 1) to assess the catecholamines and their metabolites and free cortisol in twenty four hour urine collections on subjects with sleep disorders and age, sex and weight matched controls; and 2) to asses the pituitary adrenal response to CRH test in the same subjects. We hypothesize that patients with sleep disorders associated with hyperarousal e.g. insomnia or significant sleep disruption e.g.apnea will be associated with an activation of the HPA axis while patients with disorders associated with hypoarousal i.e.idiopathic hypersomnia will be associated with hypofunctioning of the axis.