FENFLURAMINE AND PHENTERMINE TREATMENT OF SEVERE ADOLESCENT OBESITY

芬氟拉明和芬芬明治疗严重青少年肥胖症

• 批准号: 6282648
• 负责人: MICHAEL KAPLAN
• 金额: $ 0.62万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282648
• 关键词: adolescence (12-20); amphetamines; clinical research; drug screening /evaluation; fenfluramine; human subject; human therapy evaluation; obesity; weight control; weight loss

Obesity is a serious and common problem in childhood and adolescence. Being overweight as a child or teenager is associated with increased morbidity and mortality as an adult. Obese children and adolescents manifest the same metabolic risk factors (e.g. insulin resistance, hyperinsulinemia and lipoproteinemia) as obese adults. This study proposed testing the hypothesis that fenfluramine and phenetermine are safe and effective in weight loss and prevention of weight gain in adolescent patients. However, this study was terminated after publication of negative effects of the treatment.

肥胖是儿童和青少年时期的一个严重而常见的问题。 作为一个孩子或青少年超重与增加 成人的发病率和死亡率。 肥胖儿童和青少年 表现出相同的代谢危险因素（例如胰岛素抵抗， 高胰岛素血症和脂蛋白血症）。 本研究 提出测试芬氟拉明和苯乙苄胺是 安全有效的减肥和预防体重增加， 青少年患者 然而，这项研究在发表后被终止。 治疗的负面影响。