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NEUTROPHILS, CYTOKINES AND CYTOKINE RECEPTORS IN SEPTIC SHOCK

NEUTROPHILS, CYTOKINES AND CYTOKINE RECEPTORS IN SEPTIC SHOCK
感染性休克中的中性粒细胞、细胞因子和细胞因子受体
批准号：
6282752
负责人：
Charles Emory McCall
金额：
$3.63万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6282752
关键词：
clinical research cytokine receptors gene expression human subject interleukin 1 molecular pathology neutrophil septic shock tumor necrosis factor beta

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英文摘要
Human polymorphonuclear leukocytes (PMNL) synthesize, secrete, and contain specific membrane receptors for, and respond to, the cytokines II-1 alpha and beta and TNF-beta. Both of these cytokines and PMNL play an essential role in the pathogenesis of acute disseminated inflammation with organ failure which may follow microbial infection (septic shock). Dr. McCall's objective is is to show that septic shock in humans is consistently associated with amplified expression of the IL-1 beta gene.
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