INTRACATHETER NITROGLYCERIN INFUSION IN PREVENTION OF FEMORAL VENOUS THROMBOSIS

这项研究的目的是通过超声检查来调查 静脉滴注硝酸甘油对血管并发症发生率的影响 经皮股静脉置管术后血栓形成 病情危重的儿童。我们假设导管内的硝酸甘油 输液将与较低的血栓发生率相关，当 与对照导尿管相比。这项研究将包括总共62个 儿童年龄从出生到6岁。将对两组进行研究。集团化 1(硝酸甘油；n=31)将包括入院的危重儿童 初级医疗团队选择安置的重症监护病房 双腔或三腔股静脉导管。第2组(D5W；n=31) 还将包括入住重症监护室的危重儿童 初级保健团队已选择放置双倍或三倍的单位 股静脉腔内导管。超声检查对眼球的影响 股静脉插管术将由放射科进行分析 在插入导管后2天内进行检查，并进行最终研究 在出院前进行检查。主要结果是 变量是超声诊断的发病率的差异 硝酸甘油组与D5W组之间血栓形成。次要结果 变量包括血栓形成的临床证据的差异 两组导管相关感染发生率差异有统计学意义 在两组之间，TPN、脂肪乳剂和肝素输注的影响 各组血栓形成情况及导管持续时间对血栓形成的影响 在每组中。

The purpose of this study is to investigate by sonography the impact of intracatheter nitroglycerin infusion upon the incidence of vascular thrombosis following percutaneous placement of femoral venous catheters in critically ill children. We hypothesize that intracatheter nitroglycerin infusion will be associated with a lower incidence of thrombosis when compared to control catheters. The study will include a total of 62 children ages birth to 6 years of age. Two groups will be studied. Group 1 (nitroglycerin; n=31) will include critically ill children admitted to the intensive care unit in whom the primary care team has elected to place a double or triple lumen femoral venous catheter. Group 2 (D5W; n=31) will also include critically ill children admitted to the intensive care unit in whom the primary care team has elected to place a double or triple lumen femoral venous catheter. Ultrasound examinations of the catheterized femoral vein will be performed and analyzed by the Radiology investigator within 2 days of catheter insertion and a final study will be performed prior to discharge from the hospital. The primary outcome variable is the difference in the incidence of ultrasound-diagnosed thrombosis between the nitroglycerin and D5W groups. Secondary outcome variables include difference in clinical evidence of thrombosis between the two groups, difference in the incidence of catheter-related infection between the two groups, impact of TPN, intralipid, and heparin infusions on thrombosis in each group, and impact of catheter duration on thrombosis in each group.