RADIATION SENSITIVITY AND G2M DELAY IN MAMMALIAN CELLS

哺乳动物细胞的辐射敏感性和 G2M 延迟

• 批准号: 6150062
• 负责人: PETER C KENG
• 金额: $ 16.57万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6150062
• 关键词: DNA binding protein; DNA repair; RNase protection assay; cell cycle; cell cycle proteins; chemical kinetics; combination cancer therapy; cyclins; enzyme activity; gel mobility shift assay; gene expression; human tissue; interferon beta; messenger RNA; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; neoplasm /cancer photoradiation therapy; neoplastic cell; protein kinase; pulsed field gel electrophoresis; radiation sensitivity; southern blotting; tissue /cell culture

项目成果

Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-beta signaling.

高氧抑制 Mv1Lu 上皮细胞的增殖，不依赖于 TGF-β 信号传导。

• DOI: 10.1152/ajplung.1999.277.6.l1172
• 发表时间: 1999
• 期刊: The American journal of physiology
• 作者: Rancourt,RC;Staversky,RJ;Keng,PC;O'Reilly,MA
• 通讯作者: O'Reilly,MA

Absence of a radiation-induced first-cycle G1-S arrest in p53+ human tumor cells synchronized by mitotic selection.

• 发表时间: 1998-05
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: H. Nagasawa;Peter C. Keng;Carl G. Maki;Yongjia Yu;John B. Little

p53 modulates radiation sensitivity independent of p21 transcriptional activation.

p53 调节辐射敏感性，与 p21 转录激活无关。

• DOI: 10.1097/01.coc.0000139484.51715.5a
• 发表时间: 2005
• 期刊: American journal of clinical oncology
• 作者: Mazzatti,DawnJ;Lee,Yi-Jang;Helt,ChristopherE;O'Reilly,MichaelA;Keng,PeterC
• 通讯作者: Keng,PeterC

Effects of p53 mutations on cellular sensitivity to ionizing radiation.

p53 突变对细胞对电离辐射敏感性的影响。

• DOI: 10.1097/00000421-200110000-00014
• 发表时间: 2001
• 期刊: American journal of clinical oncology
• 作者: Matsui,Y;Tsuchida,Y;Keng,PC
• 通讯作者: Keng,PC