Does inhibition of myeloperoxidase attenuate atherosclerosis?

抑制髓过氧化物酶可以减轻动脉粥样硬化吗？

• 批准号: nhmrc : 1020776
• 负责人: Prof Anthony Kettle
• 金额: $ 38.18万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-inhibition-myeloperoxidase-attenuate-atherosclerosis/110066
• 关键词: Does; inhibition; myeloperoxidase; attenuate; atherosclerosis

This project examines whether inhibition of a protein that produces bleach and is part of the immune system inhibits the stiffening of arteries, i.e. the major cause of cardiovascular disease that leads to heart attack and stroke. The project uses a pharmacological approach, employing a new class of chemical compounds. If successful, the project will contribute to the establishing of a novel therapeutic target to combat cardiovascular disease.

该项目研究抑制一种产生漂白剂的蛋白质是否会抑制动脉硬化，即导致心脏病发作和中风的心血管疾病的主要原因，这种蛋白质是免疫系统的一部分。该项目采用药理学方法，采用一类新的化合物。如果成功，该项目将有助于建立一个新的治疗靶点，以对抗心血管疾病。