Potential Novel Pharmacological Strategies to Prevent Atherosclerotic Plaque Rupture

预防动脉粥样硬化斑块破裂的潜在新药理学策略

• 批准号: nhmrc : GNT1080604
• 负责人: Prof Anthony Kettle
• 金额: $ 152.33万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/potential-novel-pharmacological-plaque-rupture/1345363
• 关键词: Potential; Novel; Pharmacological; Strategies; Prevent

Most heart attacks are the consequence of the acute rupture of plaques in arteries that supply our heart with oxygen and nutrients. Current standard tests cannot distinguish plaques that likely rupture from plaques that do not rupture. Similarly, little is known about the processes that determine whether a plaque is vulnerable to rupture or stable. The current project examines the involvement of two processes - either alone or in combination - in determining plaque stability/vulnerability.

大多数心脏病发作是动脉斑块急性破裂的结果，动脉为我们的心脏提供氧气和营养。目前的标准测试不能区分可能破裂的斑块和不破裂的斑块。同样，我们对决定斑块是否容易破裂或稳定的过程知之甚少。目前的项目检查两个过程的参与-单独或组合-在确定斑块的稳定性/脆弱性。