MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET

相对 CMR02 的 MRI 测量——使用 PET 进行验证

• 批准号: 6039883
• 负责人: JOSEPH B MANDEVILLE
• 金额: $ 43.32万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6039883
• 关键词: aerobiosis; bioimaging /biomedical imaging; blood volume; brain cell; brain metabolism; cerebral cortex; clinical research; frontal lobe /cortex; hemodynamics; human subject; laboratory rat; magnetic resonance imaging; memory; method development; motor cortex; neurochemistry; neuropharmacology; neurophysiology; oxygen consumption; oxygen transport; positron emission tomography; tissue /cell culture; visual cortex; visual stimulus

This grant proposal, "MRI Measurement of Relative CMRO2: Validation using PET", is an application for an R01 award. The goal of the proposed project is to 1) develop and validate MR methods for quantitative imaging of the relative regional cerebral metabolic rate of oxygen utilization (rCMRO2) under different physiological conditions in animal models and in human volunteers, and 2) validate the relationship between changes in CMRO2 and hemodynamics in the setting of neuronally-modulated focal brain activation. The fundamental hypothesis is that MR measurements of multiple hemodynamic observables - BOLD signal, CBF, and CBV - will enable regional and temporal assessment of relative CMRO2 in agreement with positron emission tomography in rodents and humans. These studies will further test a scientific hypothesis of cerebral physiology: that changes in CMRO2 and CBF exhibit a coupling relationship in general accordance with diffusion-limited models of oxygen delivery from the blood to brain tissue, and as demonstrated by preliminary data. Within this framework we will test the basic assumptions about the relationship between MRI signals and the underlying physics and physiology and provide corroborative data for MR1 measurements of relative CMRO2 and CBF. Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology.

该赠款提案是“相对CMRO2：使用PET验证的MRI测量”，是R01奖励的申请。提议项目的目的是1）在动物模型和人类志愿者中，在不同的生理条件下，开发和验证MR方法，以定量成像，以定量成像，以验证CMRO2和血液动力学的变化之间的关系在动物模型中，在动物模型中，在动物模型中，在不同的生理条件下进行了验证。 基本假设是，多种血液动力学可观察物的MR测量 - BOLD信号，CBF和CBV - 将使相对CMRO2的区域和时间评估与啮齿动物和人类的正电子发射断层扫描一致。这些研究将进一步检验脑生理学的科学假设：CMRO2和CBF的变化通常与从血液到脑组织的扩散限制的氧递送的模型一般表现出耦合关系，并由初步数据证明。在此框架内，我们将测试有关MRI信号与基础物理学和生理学之间关系的基本假设，并为MR1测量相对CMRO2和CBF提供佐证数据。成功完成拟议的研究将建立一种评估脑功能生理学的新工具，并将这些技术应用于脑病理学。