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fMRI and neuronal activity in awake behavior

清醒行为中的功能磁共振成像和神经元活动

基本信息

批准号：
7083676
负责人：
JOSEPH B MANDEVILLE
金额：
$ 49.13万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-08-15 至 2007-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7083676
关键词：
Macaca bioimaging /biomedical imaging electrophysiology functional magnetic resonance imaging motion perception neural conduction neural information processing neuroimaging neurons visual cortex visual fields visual perception

项目摘要

DESCRIPTION (provided by applicant): Recently there has been an enormous increase in knowledge about the human brain, based on functional magnetic resonance imaging (fMRI) and related techniques. Unfortunately, fMRI does not measure neural activity directly; it only measures the response of adjacent blood vessels to the neural activity of interest. Without additional information it is difficult to interpret the local electrical activity of the neurons themselves. The proposed experiments are designed to fill this knowledge gap by directly comparing neural activity to the fMRI results, in awake behaving macaque monkeys. We plan three specific aims, in progressively higher-order regions of visual cortex, as a 'bottom-up' approach to understanding the fMRI-neural response relationship at different levels of information processing complexity. First, in primary visual cortex (area V1), we will re-test previous predictions about the neural-fMRI relationship in awake behaving macaques, and compare the extent of electrical and fMRI activity in retinotopic (visual field) coordinates. Secondly we will test the neural-fMRI relationship in MT, a visual area specialized for processing visual motion, using motion adaptation to reveal direction-selective responses. Finally, we will test the neural-fMRI relationship in a higher-order region of visual cortex which appears to be specialized for processing faces and other visual objects.

描述（由申请人提供）：

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Spatial encoding and underlying circuitry in scene-selective cortex.

DOI：
10.1016/j.neuroimage.2013.07.030
发表时间：
2013-12
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Nasr, Shahin;Devaney, Kathryn J.;Tootell, Roger B. H.
通讯作者：
Tootell, Roger B. H.

Scene-selective cortical regions in human and nonhuman primates.

DOI：
10.1523/jneurosci.2792-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Nasr S;Liu N;Devaney KJ;Yue X;Rajimehr R;Ungerleider LG;Tootell RB
通讯作者：
Tootell RB

Does Retinotopy Influence Cortical Folding in Primate Visual Cortex?