EXERCISE PREVENTS THE IMMUNOSUPPRESSIVE EFFECT OF STRESS

描述（改编自申请人摘要）：暴露于急性或 慢性压力（精神或身体）与疾病的增加有关 易感性和严重性。有证据表明压力会改变疾病 通过调节免疫系统来进行。考虑到相关的健康问题 随着反复的急性和慢性应激源暴露， 可以预防免疫学有害后果的治疗 压力源暴露一个简单的药理学方法目前是不现实的 因为应激引起的免疫变化的复杂神经激素介质 功能不理解。另一种方法是开发一种行为 干预，将缓冲压力的有害后果， 从而有助于全面改善健康状况。的初步数据 申请人实验室表明，定期、适度的体力活动 一个成功的干预能够产生这样的效果。常规，中度 运动与改善整体健康状况有关。的健康益处 体育锻炼有直接和间接两种。定期、适度的锻炼， 例如，与冠心病和高血压的减少有关。 压力，可能是由于心血管功能的直接改善。在 除了减少心脏病外，定期、适度的运动也是 与细菌和病毒性疾病的减少有关，这可能是由于 运动的间接健康益处，即，减压因此 报告的传染病减少与 运动是由于预防压力引起的免疫抑制 系统使用良好建立的应激动物模型，申请人 研究了急性应激暴露对发展的影响， 特异性抗体对良性蛋白质钥孔血蓝蛋白的反应 （KLH）.攻毒后血液中特异性抗体水平的测量 提供了体内免疫应答的极好测量， 细胞机制是很好理解的。因此，使用这种良好的特征 压力和免疫范例，申请人提出证据表明， 适度运动可以防止应激对抗KLH抗体的影响。的 因此，本研究提案的目标是更好地描述 有规律的、适度的体力活动对有害的 急性应激暴露的免疫学后果。

DESCRIPTION (Adapted from the applicant's abstract): Exposure to acute or chronic stress (mental or physical) is associated with an increase in disease susceptibility and severity. Evidence suggests that stress alters disease processes by modulating the immune system. Given the health problems associated with repeated acute and chronic stressor exposure, it is important to develop treatments which could prevent the immunologically deleterious consequences of stressor exposure. A simple pharmacological approach is currently unrealistic because the complex neurohormonal mediators of stress-induced changes in immune function are not understood. Another approach would be to develop a behavioral intervention that would buffer the deleterious consequences of stress, and thereby contribute to an overall improvement in health. Preliminary data from the applicant's laboratory suggest that regular, moderate, physical activity is a successful intervention capable of having such an effect. Regular, moderate exercise is associated with improved overall health. The health benefits of physical exercise are both direct and indirect. Regular, moderate exercise, for example, is associated with a decrease in coronary heart disease and high blood pressure, probably due to direct improvements in cardiovascular function. In addition to a reduction in heart disease, regular, moderate exercise is also associated with a decrease in bacterial and viral illness, which could be due to the indirect health benefits of exercise, i.e., stress reduction. Thus, it is possible that the reported reduction in infectious disease associated with exercise is due to the prevention of stress-induced suppression of the immune system. Using a well established animal model of stress, the applicant investigated the effect of acute stressor exposure on the development of a specific antibody response to a benign protein, keyhole limpet hemocyanin (KLH). Measurement of specific antibody levels in the blood after challenge with KLH provides and excellent measure of the in vivo immune response and the cellular mechanisms are well understood. Thus, using this well characterized stress and immunity paradigm, the applicant presents evidence that regular, moderate, exercise can prevent the effect of stress on anti-KLH antibody. The goal of this research proposal, therefore, is to better characterize the protective effect of regular, moderate physical activity on the detrimental immunological consequences of acute stressor exposure.