EXERCISE PREVENTS THE IMMUNOSUPPRESSIVE EFFECT OF STRESS

锻炼可以防止压力造成的免疫抑制作用

• 批准号: 6170376
• 负责人: MONIKA FLESHNER
• 金额: $ 7.15万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6170376
• 关键词: antibody formation; disease /disorder prevention /control; exercise; immunosuppression; laboratory rat; psychoneuroimmunology; stress

DESCRIPTION (Adapted from the applicant's abstract): Exposure to acute or chronic stress (mental or physical) is associated with an increase in disease susceptibility and severity. Evidence suggests that stress alters disease processes by modulating the immune system. Given the health problems associated with repeated acute and chronic stressor exposure, it is important to develop treatments which could prevent the immunologically deleterious consequences of stressor exposure. A simple pharmacological approach is currently unrealistic because the complex neurohormonal mediators of stress-induced changes in immune function are not understood. Another approach would be to develop a behavioral intervention that would buffer the deleterious consequences of stress, and thereby contribute to an overall improvement in health. Preliminary data from the applicant's laboratory suggest that regular, moderate, physical activity is a successful intervention capable of having such an effect. Regular, moderate exercise is associated with improved overall health. The health benefits of physical exercise are both direct and indirect. Regular, moderate exercise, for example, is associated with a decrease in coronary heart disease and high blood pressure, probably due to direct improvements in cardiovascular function. In addition to a reduction in heart disease, regular, moderate exercise is also associated with a decrease in bacterial and viral illness, which could be due to the indirect health benefits of exercise, i.e., stress reduction. Thus, it is possible that the reported reduction in infectious disease associated with exercise is due to the prevention of stress-induced suppression of the immune system. Using a well established animal model of stress, the applicant investigated the effect of acute stressor exposure on the development of a specific antibody response to a benign protein, keyhole limpet hemocyanin (KLH). Measurement of specific antibody levels in the blood after challenge with KLH provides and excellent measure of the in vivo immune response and the cellular mechanisms are well understood. Thus, using this well characterized stress and immunity paradigm, the applicant presents evidence that regular, moderate, exercise can prevent the effect of stress on anti-KLH antibody. The goal of this research proposal, therefore, is to better characterize the protective effect of regular, moderate physical activity on the detrimental immunological consequences of acute stressor exposure.

描述(改编自申请人的摘要)：接触急性或 慢性压力(精神或身体上的)与疾病的增加有关 易感性和严重性。有证据表明，压力会改变疾病 通过调节免疫系统来进行。考虑到相关的健康问题 在反复的急性和慢性应激源暴露下，重要的是发展 可以预防肺炎的免疫有害后果的治疗 应激源暴露。一种简单的药理学方法目前是不现实的 因为应激诱导的免疫变化的复杂神经激素介质 功能不被理解。另一种方法是开发一种行为 会缓冲压力的有害后果的干预措施，以及 从而有助于全面改善健康状况。初步数据来自 申请人的实验室建议，定期、适度的体力活动是 一种能够产生这种效果的成功干预。普通、中等 锻炼与改善整体健康状况有关。对健康的益处 体育锻炼既有直接的也有间接的。有规律的、适度的锻炼， 例如，与减少冠心病和高血压病有关 压力，可能是由于心血管功能的直接改善。在……里面 除了减少心脏病，定期、适度的运动也是 与细菌和病毒疾病的减少有关，这可能是由于 到锻炼的间接健康益处，即减轻压力。因此，它 报告的传染病的减少是否有可能与 运动是由于防止了应激引起的免疫抑制 系统。使用一个公认的动物应激模型，申请者 探讨急性应激源暴露对慢性应激综合征发生发展的影响。 一种良性蛋白-锁孔帽状血蓝蛋白的特异性抗体反应 (Klh)。攻击后血液中特异性抗体水平的测定 KLH提供了体内免疫反应的极佳测量和 细胞机制是很好理解的。因此，使用这个很好的特征 应激和免疫范例，申请人提出证据表明， 中度运动可预防应激对抗KLH抗体的影响。这个 因此，这项研究提案的目标是更好地描述 有规律、适度的体力活动对人体有害物质的保护作用 急性应激源暴露的免疫学后果。