Analgesia Induced by Athletic Competition

体育比赛引起的镇痛

• 批准号: 6357698
• 负责人: WENDY F STERNBERG
• 金额: $ 12.1万
• 依托单位: HAVERFORD COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6357698
• 关键词: behavior test; behavioral /social science research tag; central nervous system; exercise; female; gender difference; human subject; male; muscle stress; neuromuscular function; pain threshold; peripheral nervous system; psychobiology; psychomotor function; psychophysiology

The perception of pain is not always a true reflection of peripheral- tissue damage. There are many syndromes of severe, chronic pain that are disproportionate to the injury or condition that initiated the pain. Likewise, there are situations in which the central nervous system is capable of inhibiting the transmission of pain related information from the periphery. Acutely stressful circumstances, characterized by sympathetic nervous system (fight-or-flight) activation, are known to produce effective analgesic states in laboratory animals and humans, although relatively little is known about the common circumstances that activate endogenous pain inhibitory mechanisms in humans. This proposal will focus on the pain inhibitory effects associated with athletic competition that has been documented recently in college athletes as a model for activating the stress induced analgesia substrate in humans. The implication of athletic competition-induced analgesia is that pain loses its protective function when its inhibition allows for continued play, potentially aggravating and increasing the severity of injury and possibly contributing to chronic pain conditions and dependence on pain relieving drugs. The propensity to continue competing despite injury takes on added significance in the context of sport as a for-profit industry. The specific aims of the proposed research are to determine the analgesic (and/or hyperalgesic) effects of various types of athletic competition in male and female athletes using pain measurement tools that will allow for analysis of the psychophysical function, thereby providing an accurate measure of the degree of analgesia observed; understand the contributions of the different stressful components of athletic competition (that related to competition only, and that related to exercise) to the pain inhibitory effects of such competition in male and female subjects: determine the lone-term and short-term time course of the analgesic effects of stressful whether individual differences in pain threshold and/or tolerance contribute to athletic statu.

对疼痛的感知并不总是周围组织损伤的真实反映。有许多严重、慢性疼痛的综合症与引起疼痛的损伤或状况不成比例。同样，在某些情况下，中枢神经系统能够抑制来自外周的疼痛相关信息的传递。众所周知，以交感神经系统（战斗或逃跑）激活为特征的急性应激环境可以在实验动物和人类中产生有效的镇痛状态，尽管人们对激活人类内源性疼痛抑制机制的常见环境知之甚少。该提案将重点关注与运动竞赛相关的疼痛抑制作用，最近在大学运动员中记录了这种作用，作为激活人类应激诱导镇痛底物的模型。体育比赛引起的镇痛意味着，当疼痛的抑制允许继续比赛时，疼痛就会失去其保护功能，可能会加重和增加损伤的严重性，并可能导致慢性疼痛状况和对止痛药物的依赖。在体育作为一个营利性行业的背景下，尽管受伤仍继续参加比赛的倾向变得更加重要。拟议研究的具体目的是使用疼痛测量工具确定男女运动员各种类型运动竞赛的镇痛（和/或痛觉过敏）效果，该工具将允许分析心理物理功能，从而提供所观察到的镇痛程度的准确测量；了解体育竞赛的不同压力成分（仅与竞赛相关，以及与运动相关）对男性和女性受试者中此类竞赛的疼痛抑制作用的贡献：确定压力镇痛作用的单长期和短期时间过程，疼痛阈值和/或耐受性的个体差异是否会影响运动状态。