FASEB CONFERENCE-- CILIATE MOLECULAR BIOLOGY

描述(申请人提供)：申请部分资助“第八届纤毛虫分子生物学国际会议”。这次会议 将作为FASEB会议在萨克斯顿河的佛蒙特州学院举行， 佛蒙特州，2001年7月28日-8月2日。这次会议将把 使用分子方法研究不同种类的 以纤毛原生动物为模型系统的生物学问题。伟大的 纤毛虫的价值源于它们不同寻常的遗传组织和广泛的， 基因组的发育程序化重组。这些功能具有 提供了对基本染色体阵列的非凡洞察力 过程，包括发现自剪接RNA、端粒和 端粒酶和组蛋白乙酰转移酶对染色质的重塑。近期 研究进展，如通过同源重组进行靶向基因置换和 有意义的核糖体已经被用来研究广泛的问题 细胞和分子生物学，从端粒和端粒酶，到 微管调节蛋白分泌对微管蛋白修饰的影响 集合。研究的步伐加快了，因为发展和 推广新的实验方法。由于这一原因和其他原因， 纤毛虫分子生物学会议填补了一个关键的利基市场 缺少其他科学会议。1999年的会议包括一个讲习班 评估四膜虫基因组的实际问题和合理性 测序项目。人类生物学和医学的大范围领域 可能会受到这个项目的有利影响。随后的会议将扮演一个 发挥重要的组织作用，并将促进努力产生 推进这一项目需要集体承诺。 纤毛虫分子生物学会议将组织成九个平台 会议和两个海报会议。平台会议将涵盖前沿 研究主题包括染色质重塑、端粒和端粒酶、DNA 重排，DNA复制，信号转导，细胞骨架， 进化和基因组可塑性。约170家国内外企业 科学家将出席会议。这次会议的组织者是 杰弗里·凯普勒博士(DNA复制，德克萨斯A&M)，Jacek Gairtig博士(The 细胞骨架，佐治亚大学(UG))和Laura Landweber博士(进化论， 普林斯顿大学)。

DESCRIPTION (provided by applicant): Partial support is requested for the "Eighth International Meeting on Ciliate Molecular Biology." This meeting will be held as a FASEB Conference at the Vermont Academy in Saxtons River, Vermont, July 28 - August 2, 2001. The meeting will bring together researchers who employ molecular approaches for investigating diverse biological problems using ciliated protozoa as their model system. The great value of ciliates stems from their unusual genetic organization and extensive, developmentally-programmed reorganization of the genome. These features have provided remarkable insights into an array of fundamental chromosomal processes, including the discovery of self-splicing RNA, telomeres and telomerase, and chromatin remodeling by histone acetyltransferases. Recent advances, such as targeted gene replacement by homologous recombination and intisense ribosomes have been exploited to study a wide range of questions in cell and molecular biology, ranging from telomeres and telomerase, to regulated protein secretion, to tubulin modification during microtubule assembly. The pace of research has quickened due to the development and dissemination of new experimental methods. For this reason and others, the Ciliate Molecular Biology Meeting fills a critical niche that is otherwise lacking in other scientific meetings. The 1999 meeting included a workshop for assessing practical issues and justification for a Tetrahymena genome sequencing project. A large spectrum of areas in human biology and medicine could be favorably impacted by this project. Subsequent meetings will play an important organizational role and will facilitate efforts to generate the collective commitment needed to move this project forward. The Ciliate Molecular Biology meeting will be organized into nine platform sessions and two poster sessions. Platform sessions will cover leading edge research topics including chromatin remodeling, telomeres and telomerase, DNA rearrangement, DNA replication, signal transduction, the cytoskeleton, evolution, and genome plasticity. Approximately 170 foreign and domestic scientists will attend the meeting. The organizers for this conference are Dr. Geoffrey Kapler (DNA replication, Texas A&M), Dr. Jacek Gaertig (the cytoskeleton, University of Georgia (UG)) and Dr. Laura Landweber (evolution, Princeton University).