Third Int'l Conference on Reactive Nitrogen Species

第三届活性氮国际会议

• 批准号: 6364255
• 负责人: JOSEPH S BECKMAN
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-20 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6364255
• 关键词: cardiovascular disorder; meeting /conference /symposium; neural degeneration; nitric oxide; peroxynitrites

DESCRIPTION (provided by applicant): We request support principally to fund travel awards for young investigators to attend and present at the Third International Conference on Reactive Nitrogen Species and Peroxynitrite in Biology and Medicine. This is the only meeting focusing entirely upon the physiological and pathological effects of peroxynitrite and other reactive nitrogen species derived from nitric oxide in biological systems. Peroxynitrite is a powerful oxidant formed by the reaction of nitric oxide with superoxide and is implicated in amyotrophic lateral sclerosis, Parkinson's disease, inflammation and vascular disease. The conference will bring together chemists, biologists and physicians to unravel the complex biological chemistry and physiological actions of these reactive intermediates. NIH currently funds 145 applications on peroxynitrite alone, investigating its roles in neurodegenerative diseases, respiratory distress, cardiovascular disorders, cancer and other disorders. Over half of the participants at the two previous meetings were post docs and graduate students, several of whom are now becoming established investigators in the field. The two previous meetings have helped shaped current research on peroxynitrite and resolve fundamental issues about the chemistry of these reactive intermediates. Scavengers of peroxynitrite, first described at the first two meetings, have now been shown to be effective in animal models of multiple sclerosis and amyotrophic lateral sclerosis. The third international meeting will be held at the Asilomar Conference Center near Monterey, CA. The format will be similar to a Gordon conference with morning oral presentations followed by group discussions in the evening. The objectives are to exchange information and engage in discussions across the disciplines of chemistry, biology and medicine of peroxynitrite and other reactive nitrogen species. The meeting is an important focal point for the great diversity of scientific disciplines and talents working with peroxynitrite and other reactive nitrogen species and provides an important opportunity to attract young investigators to the field.

描述（由申请人提供）：我们请求支持，主要是为了资助 青年调查员出席第三届 活性氮和过氧亚硝酸盐国际会议 生物学和医学。这是唯一一次完全集中在 过氧亚硝酸盐的生理和病理作用以及其他反应性 生物系统中源自一氧化氮的氮物质。过氧亚硝基 是一种强大的氧化剂，由一氧化氮与超氧化物反应形成 与肌萎缩性侧索硬化症，帕金森病， 炎症和血管疾病。会议将汇集化学家， 生物学家和医生来解开复杂的生物化学， 这些活性中间体的生理作用。目前，国家卫生研究院资助145 应用过氧亚硝酸盐单独，调查其作用， 神经变性疾病、呼吸窘迫、心血管疾病， 癌症和其他疾病。在前两届会议上， 会议是博士后和研究生，其中一些人现在正在成为 在实地设立调查员。前两次会议有助于 形成了目前对过氧亚硝酸盐的研究，并解决了有关 这些活性中间体的化学性质。过氧亚硝酸盐的清除剂， 最初在前两次会议上描述的，现在已被证明是有效的 多发性硬化症和肌萎缩性侧索硬化症的动物模型。的 第三次国际会议将在阿西洛马会议中心举行， 加利福尼亚州蒙特雷。形式将类似于戈登会议与上午 口头报告，然后在晚上进行小组讨论。目标 交流信息并参与跨学科的讨论， 过氧亚硝酸盐及其它活性氮化学、生物学和医学 物种这次会议是一个重要的焦点， 科学学科和人才与过氧亚硝酸盐和其他工作 活性氮物种，并提供了重要的机会，吸引 年轻的研究人员到外地。