Aging and Endothelial Function of Muscle Arterioles
Aging and Endothelial Function of Muscle Arterioles
批准号:
6319123
负责人:
JUDY M DELP
金额:
$20.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2003-03-31
关键词:
aging animal old age arterioles enzyme inhibitors exercise gastrocnemius muscle gene expression laboratory rat mature animal messenger RNA microcirculation musculoskeletal circulation nitric oxide nitric oxide synthase polymerase chain reaction prostaglandin endoperoxide synthase prostaglandins striated muscles tissue /cell preparation vascular endothelium vascular resistance vasodilation vasodilators
中文摘要
描述:(原文来自应用)骨骼肌灌注和
英文摘要
DESCRIPTION: (Verbatim from application) Skeletal muscle perfusion and
endothelium-mediated vasodilation of the skeletal muscle resistance vasculature
appear to diminish with advancing age; however, the precise mechanisms that
underlie aging-induced decrements in vasodilatory function of the skeletal
muscle vasculature are unclear. Our recent work has documented impaired
flow-induced vasodilation in 1A arterioles from soleus and gastrocnemius
muscles of aged Fischer 344 rats. Although flow-induced vasodilation of
skeletal muscle arterioles is known to be an endothelium-dependent response,
the mechanisms of the response have not been defined in arterioles from
locomotory muscles, such as the soleus and gastrocnemius muscles, and
furthermore, the mechanisms which underlie the aging-induced impairment of this
response are not known. Therefore, we propose to investigate the contribution
of endothelium-dependent vasodilatory pathways to flow-induced vasodilation in
soleus and gastronemius muscle arterioles from young and aged Fisher 344 rats.
We will test the hypothesis that the aging-induced impairment of flow-induced
vasodilation in these resistance arterioles occurs primarily due to a decrease
in the ability of the endothelium to produce prostanoid vasodilators. We will
use specific inhibitors of key enzymes to determine which component(s) of the
flow-induced vasodilation, i.e., endothelial nitric oxide (NO), prostanoid
vasodilators, or endothelium-derived hyperpolarizing factor (EDEHF), is
downregulated in arterioles from old animals (Aim 1). We will determine whether
decreases in protein and mRNA expression for the constitutive form of
cyclooxygenase (COX-1) and endothelial nitric synthase (ecNOS) potentially
underlie reduced production of No and prostanoid vasodilators in response to
flow in arterioles from old rats (Aim2). Finally, because an increased tendency
toward more sedentary behavior occurs with advancing age and because exercise
training has been shown to improve endothelium-dependent vasodilation of the
skeletal muscle vasculature, we propose to determine whether exercise training
can ameliorate the impaired flow-induced vasodilation that occurs in skeletal
muscle arterioles from aged rats (Aim 3). Although aging has been documented to
reduce skeletal muscle vasodilatory responses, these studies will be the first
to evaluate the endothelial mechanisms responsible for the loss of vasodilatory
function. Furthermore, these studies will determine whether exercise training
can counter the aging-associated loss of endothelium-dependent vasodilatory
responses in skeletal muscle resistance arterioles.
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专著(0)
科研奖励(0)
会议论文
Role of Adiponectin in Reversal of Age-related Vascular Dysfunction
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批准号:10566303
-
项目类别:
-
资助金额:$52.09万
-
财政年份:2023
-
负责人:JUDY M DELP
-
依托单位:
Microvascular Aging and eNOS Uncoupling
-
批准号:7729353
-
项目类别:
-
资助金额:$41.47万
-
财政年份:2009
-
负责人:JUDY M DELP
-
依托单位:
Microvascular Aging and eNOS Uncoupling
-
批准号:7923952
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项目类别:
-
资助金额:$41.01万
-
财政年份:2009
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:6921769
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项目类别:
-
资助金额:$13.29万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7247709
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项目类别:
-
资助金额:$6.1万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7221294
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项目类别:
-
资助金额:$33.32万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7391188
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项目类别:
-
资助金额:$10.82万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7054082
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项目类别:
-
资助金额:$34.36万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7147409
-
项目类别:
-
资助金额:$23.09万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging, Estrogen, and Coronary Endothelial Function
-
批准号:7743909
-
项目类别:
-
资助金额:$22.46万
-
财政年份:2005
-
负责人:JUDY M DELP
-
依托单位:
Aging and Endothelial Function of Muscle Arterioles
-
批准号:6509968
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项目类别:
-
资助金额:$21.28万
-
财政年份:2001
-
负责人:JUDY M DELP
-
依托单位:
MECHANISMS OF ARTERIOLAR FLOW INDUCED VASODILATION
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批准号:2213826
-
项目类别:
-
资助金额:$2.86万
-
财政年份:1995
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负责人:JUDY M DELP
-
依托单位:
MECHANISMS OF ARTERIOLAR FLOW INDUCED VASODILATION
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批准号:2213825
-
项目类别:
-
资助金额:$2.37万
-
财政年份:1994
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负责人:JUDY M DELP
-
依托单位:
MECHANISMS OF ARTERIOLAR FLOW-INDUCED VASODILATION
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批准号:2213824
-
项目类别:
-
资助金额:$2.16万
-
财政年份:1994
-
负责人:JUDY M DELP
-
依托单位: