Does mitochondrial metabolism in neurons act to link peripheral metabolic state to motivated food-seeking behaviour?

神经元中的线粒体代谢是否能够将外周代谢状态与动机性食物寻求行为联系起来？

• 批准号: nhmrc : 1072364
• 负责人: Dr Sarah Lockie
• 金额: $ 22.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-mitochondrial-metabolism-seeking-behaviour/455506
• 关键词: Does; mitochondrial; metabolism; neurons; act

Obesity, and its associated pathologies, is a major disease concern. The brain systems that regulate food intake and body weight break down under the strain of obesity and this creates a vicious cycle where failure to regulate metabolism promotes further weight gain. I am investigating how the mitochondrial enzyme CPT1c regulates these brain systems, and whether obesity impairs CPT1c function. Understanding CPT1c function in the brain will help us understand the causes of obesity and diabetes.

肥胖及其相关病理是一个主要疾病问题。在肥胖的压力下，调节食物摄入和体重的大脑系统会崩溃，这就造成了一个恶性循环，即不能调节新陈代谢会促进体重的进一步增加。我正在研究线粒体酶CPT1c如何调节这些大脑系统，以及肥胖是否会损害CPT1c功能。了解CPT1c在大脑中的功能将有助于我们了解肥胖和糖尿病的原因。