Does mitochondrial metabolism in neurons act to link peripheral metabolic state to motivated food-seeking behaviour?

肥胖及其相关的病理因素是一个主要的疾病问题。在肥胖的压力下，调节食物摄入量和体重的大脑系统崩溃，这造成了一个恶性循环，未能调节新陈代谢会进一步增加体重。我正在研究线粒体酶CPT1c是如何调节这些大脑系统的，以及肥胖是否会损害CPT1c的功能。了解CPT1c在大脑中的功能将有助于我们了解肥胖和糖尿病的原因。

Obesity, and its associated pathologies, is a major disease concern. The brain systems that regulate food intake and body weight break down under the strain of obesity and this creates a vicious cycle where failure to regulate metabolism promotes further weight gain. I am investigating how the mitochondrial enzyme CPT1c regulates these brain systems, and whether obesity impairs CPT1c function. Understanding CPT1c function in the brain will help us understand the causes of obesity and diabetes.